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  • Description:
  • TMP269 promotes pro‐inflammatory cytokine production in macrophages. A and B, Time‐course production of IL‐6 (A) and TNF‐α (B) by 24‐h LPS‐stimulated bone marrow‐derived macrophages treated with either TMP269 or vehicle in vitro as determined by ELISA. C, Representative flowcytometry data of intracellular production of IL‐6 and TNF‐α by macrophages in the injured spinal cords of vehicle group and TMP269 group at 3 days post‐injury. Positive cells were gated in CD45+Gr‐1−CD11b+ macrophages/microglia. D and E, Statistical analysis of percentage of IL‐6+ (D) and TNF‐α+ (E) cells in CD45+Gr‐1−CD11b+ macrophages/microglia in injured spinal cords of vehicle group and TMP269 group during first 2 weeks post injury. Each group contained five mice. Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ns, not significant
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2018 Wiley Periodicals, Inc.
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 623 x 279
  • Image File Size:
  • 97.7 KB
  • Creator:
  • Xiangbei Qi, Pengcheng Wang
  • Credit:
  • Qi, X., Wang, P., Xiong, Y., Mahmood, A., Chopp, M., Amar, A., Levy, M., Gao, H., Hong, J., Martinez, F., Helming, L., Gordon, S., Serhan, C., Savill, J., Murray, P., Wynn, T., Popovich, P., Wei, P., Stokes, B., Kigerl, K., Gensel, J., Ankeny, D., Alexander, J., Donnelly, D., Popovich, P., Lu, P., Jones, L., Snyder, E., Tuszynski, M., de Ruijter, A., van Gennip, A., Caron, H., Kemp, S., van Kuilenburg, A., Marks, P., Rifkind, R., Richon, V., Breslow, R., Miller, T., Kelly, W., Halili, M., Andrews, M., Labzin, L., Jeong, Y., Du, R., Zhu, X., Cheng, F., Lienlaf, M., Perez‐Villarroel, P., Fischle, W., Dequiedt, F., Hendzel, M., Lahm, A., Paolini, C., Pallaoro, M., Fleming, C., Ashton, T., Gaur, V., McGee, S., Pfeffer, F., Martin, M., Kettmann, R., Dequiedt, F., Guerriero, J., Sotayo, A., Ponichtera, H., Lobera, M., Madauss, K., Pohlhaus, D., Rius, J., Guma, M., Schachtrup, C., Basso, D., Beattie, M., Bresnahan, J., Timmermann, S., Lehrmann, H., Polesskaya, A., Harel‐Bellan, A., Abdanipour, A., Schluesener, H., Tiraihi, T., Aung, H., Schroder, K., Himes, S., Wang, G., Shi, Y., Jiang, X., Bredy, T., Wu, H., Crego, C., Zellhoefer, J., Sun, Y., Barad, M., Wu, X., Chen, P., Dallas, S., Koppel, I., Timmusk, T., Lu, J., McKinsey, T., Nicol, R., Olson, E., Darnell, J., Kerr, I., Stark, G., Bonizzi, G., Karin, M., Verdin, E., Dequiedt, F., Kasler, H., Wang, B., Rao, Y., Inoue, M., Yan, B., Xie, S., Liu, Z., Sharp, J., Frame, J., Siegenthaler, M., Nistor, G., Keirstead, H., Emery, B., & Lu, Q. (2018). Class IIa HDACs inhibitor TMP269 promotes M1 polarization of macrophages after spinal cord injury. Journal of Cellular Biochemistry, 119(4), 3081-3090. https://doi.org/10.1002/jcb.26446.
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  • Keywords:
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  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Xiangbei Qi, Pengcheng Wang
  • Article Copyright Year:
  • 2018
  • Publication Volume:
  • 119
  • Publication Issue:
  • 4
  • Publication Date:
  • 04/01/2018
  • DOI:
  • https://doi.org/10.1002/jcb.26446

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