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  • Description:
  • TCDD‐induced cholinergic anti‐inflammation suppresses proliferation and secretion of proinflammatory cytokines by encephalitogenic T cells. (A) Proliferation of CD4+ cells from EAE mice 9 days after immunization and restimulated with MOG35–55 for 3 days. (B) Proliferation of CD4+ cells from control‐treated mice transfected with mim‐miR‐132 or scramble nucleotides before restimulation. (C) Proliferation of CD4+ cells from TCDD‐treated mice transfected with as‐miR‐132 or scramble nucleotides, and cells from control‐treated EAE mice were transfected with scramble nucleotides. Proliferation is expressed as stimulation index (SI) = A570 of unstimulated cells/A570 of MOG35–55‐stimulated cells. (A, B) ANOVA test; *p < 0.05, **p < 0.01. (C) ANOVA test; *p < 0.05 control versus as‐miR‐132; †p < 0.05, ††p < 0.01 TCDD versus TCDD+as‐miR‐132. (D) Cytokines in culture supernatants of CD4+ cells prepared as described in (A). T cells from control‐treated mice were transfected with mim‐miR‐132 or scramble nucleotides, and cells from TCDD‐treated mice were transfected with scramble nucleotides. (D) Student's t‐test; **p < 0.01, ***p < 0.001. Data are shown as mean ± SD of n = 5 (A–C) and n = 8 (D) per group and are from one experiment representative of three performed.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 1333 x 889
  • Image File Size:
  • 770 KB
  • Creator:
  • Hanieh Hamza, Alzahrani Abdullah
  • Credit:
  • Hamza, H., & Abdullah, A. (2013). MicroRNA‐132 suppresses autoimmune encephalomyelitis by inducing cholinergic anti‐inflammation: A new Ahr‐based exploration. European Journal of Immunology, 43(10), 2771-2782. https://doi.org/10.1002/eji.201343486.
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Hanieh Hamza, Alzahrani Abdullah
  • Article Copyright Year:
  • 2013
  • Publication Volume:
  • 43
  • Publication Issue:
  • 10
  • Publication Date:
  • 10/01/2013
  • DOI:
  • https://doi.org/10.1002/eji.201343486

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