Asset Details

  • Description:
  • Proposed schematic of intracellular immune response to MNVs infection. MNV may infect macrophages or DCs in the gut. Infected cells sense MNV via MDA‐5 and produce IFNs through this or the STAT‐1 pathway. Type I IFNs inhibit MNV uncoating via ISG15 and may inhibit replication complex formation via an Atg complex. Type II IFNs block MNV translation via RNA‐activated protein kinase (PKR). VF1‐related immune suppression by MNV is not included in this schematic.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 933 x 525
  • Image File Size:
  • 2.05 MB
  • Creator:
  • Kira L. Newman, Juan S. Leon
  • Credit:
  • Newman, K. L., & Leon, J. S. (2015). Norovirus immunology: Of mice and mechanisms. European Journal of Immunology, 45(10), 2742-2757. https://doi.org/10.1002/eji.201545512.
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Kira L. Newman, Juan S. Leon
  • Article Copyright Year:
  • 2015
  • Publication Volume:
  • 45
  • Publication Issue:
  • 10
  • Publication Date:
  • 10/01/2015
  • DOI:
  • https://doi.org/10.1002/eji.201545512

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