Asset Details

  • Description:
  • Diagrams depicting ligand–receptor interactions with the extracellular domain of the p75 receptor. (A) Ligands binding directly or indirectly to p75 and known to be efficiently axonally transported and transcytosed. The four cystein‐rich domains (CRD) of p75 are indicated. The natural ligands, the neurotrophins (NTs, shown as a pair of black ovals), bind to the 2nd and 3rd CRD of p75. Precise sites of binding of β‐amyloid (β‐AM) and prion peptides (PrP) within the extracellular portion of p75 are not yet known. Wheat germ agglutinin (WGA, shown as a pair of dark circles) binds to the N‐glycosylation site on the 1st CRD. Rabies virus glycoprotein (RVG, single black circle) also binds to the 1st CRD. Tetanus toxin (TeT) binds to the ganglioside GT1b which associates with p75. Cholera toxin (CTB) binds the ganglioside GM1 which associates with trk receptor which in turn associates with p75, thus possibly forming a p75–trk–GM1–CTB complex. (B) Ligands and receptors which associate with p75 and for which transport and transcytosis is yet unknown. The ligands MAG (myelin‐associated glycoprotein), Nogo66 and OMG (oligodendrocyte‐myelin glycoprotein) bind the Nogo receptor (NogoR). This receptor interacts with the p75 receptor. Pro‐nerve growth factor (ProNGF) presumably binds to the same site (2nd and 3rd CRD) on p75 as the mature neurotrophins.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © Federation of European Neuroscience Societies
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 500 x 493
  • Image File Size:
  • 25.3 KB
  • Creator:
  • Rafal Butowt, Christopher S. Von Bartheld
  • Credit:
  • Butowt, R., & Von Bartheld, C. S. (2003). Connecting the dots: trafficking of neurotrophins, lectins and diverse pathogens by binding to the neurotrophin receptor p75NTR. European Journal of Neuroscience, 17(4), 673-680. https://doi.org/10.1046/j.1460-9568.2003.02497.x.
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Rafal Butowt, Christopher S. Von Bartheld
  • Article Copyright Year:
  • 2003
  • Publication Volume:
  • 17
  • Publication Issue:
  • 4
  • Publication Date:
  • 02/01/2003
  • DOI:
  • https://doi.org/10.1046/j.1460-9568.2003.02497.x

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