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  • Description:
  • . (A) Kinetics of torasemide uptake by wild‐type OATP1B1. Data were fit to the Michaelis‐Menten equation after subtracting background uptake in cells transfected with the vector only. Data points represent the mean ± SEM from 3 independent experiments. (B) Uptake of torasemide into transiently transfected (1.5 μg plasmid DNA/300.000 cells) HEK293 cells expressing human OATP1B1 (wild‐type), OATP1B1 p.130Asn>Asp (SLCO1B1 c.388A>G), and OATP1B1 p.174Val>Ala (SLCO1B1 c.521T>C). Data are shown as mean ± SEM of 3 uptake experiments (P < .05 wild‐type vs c.521T>C, 2‐way analysis of variance).
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • 2010 American College of Clinical Pharmacology
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 652 x 822
  • Image File Size:
  • 49.4 KB
  • Creator:
  • Ulrike Werner, PhD, Dierk Werner, MD, Svetlana Heinbüchner, MD, Bernhard Graf, MD, Hüseyin Ince, MD, Stefan Kische, MD, Petra Thürmann, MD, Jörg König, PhD, Martin F. Fromm, MD, Oliver Zolk, MD
  • Credit:
  • Werner, U., Werner, D., Heinbüchner, S., Graf, B., Ince, H., Kische, S., Thürmann, P., König, J., Fromm, M. F., & Zolk, O. (2010). Gender Is an Important Determinant of the Disposition of the Loop Diuretic Torasemide. The Journal of Clinical Pharmacology, 50(2), 160-168. https://doi.org/10.1177/0091270009337514.
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  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Ulrike Werner, PhD, Dierk Werner, MD, Svetlana Heinbüchner, MD, Bernhard Graf, MD, Hüseyin Ince, MD, Stefan Kische, MD, Petra Thürmann, MD, Jörg König, PhD, Martin F. Fromm, MD, Oliver Zolk, MD
  • Article Copyright Year:
  • 2010
  • Publication Volume:
  • 50
  • Publication Issue:
  • 2
  • Publication Date:
  • 02/01/2010
  • DOI:
  • https://doi.org/10.1177/0091270009337514

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