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  • Description:
  • Involvement of P2Y6 receptors in pressure overload‐induced cardiac fibrosis. Effects of MRS2578 (3 mg/kg/day, started from 3 days after TAC surgery) on TAC‐induced fibrosis and hypertrophy (A–C), and LV functions (D, E). (A) Hearts (left; scale bar, 2 mm), H&E staining (center; scale bar, 30 μm), and picrosirius red staining (right; scale bar, 200 μm). (B) CSA of cardiomyocytes. (C) Results of cardiac fibrosis. (F) Expression of hypertrophic and fibrogenic genes. (G) Effects of MRS2678 on TAC‐induced Rho activation and the expression of periostin, mature TGF‐βs, ACE, and GAPDH. GAPDH was used as an internal control. Error bars indicate s.e.m.; n=3–8 (B, C), n=8–12 (D, E), n=5–7 (F), and n=3 (G, H). Representative result of hearts from vehicle‐sham (n=3), vehicle‐TAC (n=7), and MRS‐sham (n=3), and MRS‐TAC mice (n=8) was shown (A). * indicates P<0.05, ** indicates P<0.01, and *** indicates P<0.001.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Copyright © 2013 Wiley Periodicals, Inc
  • Asset Type:
  • Image
  • Asset Subtype:
  • Photo
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 719 x 1018
  • Image File Size:
  • 334 KB
  • Creator:
  • Motohiro Nishida, Yoji Sato, Aya Uemura, Yusuke Narita, Hidetoshi Tozaki‐Saitoh, Michio Nakaya, Tomomi Ide, Kazuhiro Suzuki, Kazuhide Inoue, Taku Nagao, Hitoshi Kurose
  • Credit:
  • Nishida, M., Sato, Y., Uemura, A., Narita, Y., Tozaki‐Saitoh, H., Nakaya, M., Ide, T., Suzuki, K., Inoue, K., Nagao, T., & Kurose, H. (2008). P2Y6 receptor‐Gα12/13 signalling in cardiomyocytes triggers pressure overload‐induced cardiac fibrosis. The EMBO Journal, 27(23), 3104-3115..
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Motohiro Nishida, Yoji Sato, Aya Uemura, Yusuke Narita, Hidetoshi Tozaki‐Saitoh, Michio Nakaya, Tomomi Ide, Kazuhiro Suzuki, Kazuhide Inoue, Taku Nagao, Hitoshi Kurose
  • Article Copyright Year:
  • 2008
  • Publication Volume:
  • 27
  • Publication Issue:
  • 23
  • Publication Date:
  • 12/03/2008
  • DOI:

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