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  • Description:
  • Confocal microscope images of a reactive microglial cell in the cortex of an epileptic rat (3 months after status epilepticus) shows intracellular presence of ferritin (A) and (mainly membranous) OX‐42 staining (B). C: Merged image. D–F: Detail of dentate gyrus (DG) of chronic epileptic rat (p‐SE, 5 months) shows strong ferritin staining in cells with microglial morphology cells and weak ferritin staining in granule cells (D–E). F: Merged image. G, H: Merged images of ferritin (red) and NeuN (green) in DG of control and 1‐week post‐SE rat (latent period). I: Image of ferritin immunoreactivity (red) and the reactive astrocytes marker vimentin (green) in the hilar region of a 1‐week animal. Note that no colocalization appears between ferritin and vimentin. White arrow, Example of a blood vessel labeled with vimentin. J–L: Ferritin staining (red) combined with NeuN (green, J–K) or vimentin (green, L) in control (J) and chronic epileptic rat (K, L: pSE, 5 months). Note that ferritin‐positive cells with microglial morphology in layer III of epileptic rats are much larger than ferritin‐positive cells in control rat. Also note that only blood vessels are stained by vimentin; vimentin‐positive astrocytes are much rarer at this stage. Calibration bar: A–C, 10 μm; D–F, 20 μm; J–L, 40 μm.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Asset Type:
  • Image
  • Asset Subtype:
  • Photo
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 400 x 524
  • Image File Size:
  • 139 KB
  • Creator:
  • Jan A. Gorter, Ana R.M. Mesquita, Erwin A. Van Vliet, Fernando H. Lopes Da Silva, Eleonora Aronica
  • Credit:
  • Gorter, J. A., Mesquita, A. R. M., Van Vliet, E. A., Da Silva, F. H. L., & Aronica, E. (2005). Increased Expression of Ferritin, an Iron‐storage Protein, in Specific Regions of the Parahippocampal Cortex of Epileptic Rats. Epilepsia, 46(9), 1371-1379. https://doi.org/10.1111/j.1528-1167.2005.11505.x.
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  • Keywords:
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  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Jan A. Gorter, Ana R.M. Mesquita, Erwin A. Van Vliet, Fernando H. Lopes Da Silva, Eleonora Aronica
  • Article Copyright Year:
  • 2005
  • Publication Volume:
  • 46
  • Publication Issue:
  • 9
  • Publication Date:
  • 09/01/2005
  • DOI:
  • https://doi.org/10.1111/j.1528-1167.2005.11505.x

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