Asset Details

  • Description:
  • Probing the thrombin‐induced signaling pathway in primary human macrophages. (A) Various signal transduction inhibitors or agonists (SP600125, 0.3 μM; DEX, 100 nM; TRAP‐6, 200 μM; U0126, 1 μM; C3, 10 ug/ml) were used to probe the thrombin‐stimulated signal transduction pathway in primary human macrophages. (B) RelA nuclear translocation was determined in primary macrophages with immunostaining. The nuclei were stained with DAPI and pseudo‐colored in red. The RelA is immunolabeled in green. The top panel is an immunolabeling of thrombin‐treated human macrophage with only the secondary antibody (no anti‐RelA primary antibody used) serving as the control for the specificity of the immunolabeling. The results represent one of two independent experiments.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © Society for Leukocyte Biology
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • x
  • Image File Size:
  • 353 KB
  • Creator:
  • Lei Zheng, Manuela Martins‐Green
  • Credit:
  • Zheng, L., & Martins‐Green, M. (2007). Molecular mechanisms of thrombin‐induced interleukin‐8 (IL‐8/CXCL8) expression in THP‐1‐derived and primary human macrophages. Journal of Leukocyte Biology, 82(3), 619-629. https://doi.org/10.1189/jlb.0107009.
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Lei Zheng, Manuela Martins‐Green
  • Article Copyright Year:
  • 2007
  • Publication Volume:
  • 82
  • Publication Issue:
  • 3
  • Publication Date:
  • 09/01/2007
  • DOI:
  • https://doi.org/10.1189/jlb.0107009

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