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  • Description:
  • Schematic diagram illustrating metabolites of the glycolytic pathway and the TCA cycle that are altered by ARRB1. In red are metabolites or genes showing increased concentration or expression, respectively, in nucARRB1; in blue are those with lower concentration or expression, respectively. Reductive carboxylation pathway of glutamine is indicated in green. Modulation of HIF1A signalling by ARRB1 occurs at two levels: (i) ARRB1 indirectly alters expression levels of metabolic enzymes FH and SDHA, resulting in accumulation of oncometabolites fumarate and succinate and pseudohypoxic stabilisation of HIF1A, and (ii) ARRB1 acts as a co‐factor of HIF1A to enhance its transcriptional activity both in normoxic and hypoxic conditions.
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  • CC-BY
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  • Rights Managed by John Wiley & Sons
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  • © 2014 EMBO
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  • Image
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  • Portrait
  • Image Dimensions:
  • 685 x 1084
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  • 248 KB
  • Creator:
  • Vincent Zecchini, Basetti Madhu, Roslin Russell, Nelma Pértega‐Gomes, Anne Warren, Edoardo Gaude, Joana Borlido, Rory Stark, Heather Ireland‐Zecchini, Roheet Rao, Helen Scott, Joan Boren, Charlie Massie, Mohammad Asim, Kevin Brindle, John Griffiths, Christian Frezza, David E Neal, Ian G Mills
  • Credit:
  • Ackerstaff, E., Pflug, B., Nelson, J., Bhujwalla, Z., Aragones, J., Fraisl, P., Baes, M., Carmeliet, P., Barski, A., Cuddapah, S., Cui, K., Roh, T., Schones, D., Wang, Z., Wei, G., Chepelev, I., Zhao, K., Benjamini, Y., Hochberg, Y., Bernstein, J., Bernstein, C., West, C., Homer, J., Boren, J., Lee, W., Bassilian, S., Centelles, J., Lim, S., Ahmed, S., Boros, L., Cascante, M., Buchanan, F., Gorden, D., Matta, P., Shi, Q., Matrisian, L., DuBois, R., Cardaci, S., Ciriolo, M., Chung, C., Ciampa, J., Yeager, M., Jacobs, K., Berndt, S., Hayes, R., Gonzalez‐Bosquet, J., Kraft, P., Wacholder, S., Orr, N., Yu, K., Hutchinson, A., Boland, J., Chen, Q., Feigelson, H., Thun, M., Diver, W., Albanes, D., Virtamo, J., Weinstein, S., Covello, K., Simon, M., Keith, B., Dahia, P., Ross, K., Wright, M., Hayashida, C., Santagata, S., Barontini, M., Kung, A., Sanso, G., Powers, J., Tischler, A., Hodin, R., Heitritter, S., Moore, F., Dluhy, R., Sosa, J., Ocal, I., Benn, D., Marsh, D., Robinson, B., Schneider, K., Dang, C., Dasgupta, P., Rastogi, S., Pillai, S., Ordonez‐Ercan, D., Morris, M., Haura, E., Chellappan, S., Dasgupta, P., Rizwani, W., Pillai, S., Davis, R., Banerjee, S., Hug, K., Lloyd, M., Coppola, D., Haura, E., Chellappan, S., DeBerardinis, R., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., Thompson, C., Des Rosiers, C., Donato, L., Comte, B., Laplante, A., Marcoux, C., David, F., Fernandez, C., Brunengraber, H., Dunning, M., Smith, M., Ritchie, M., Tavaré, S., Gedaily, A., Bubendorf, L., Willi, N., Fu, W., Richter, J., Moch, H., Mihatsch, M., Sauter, G., Gasser, T., Favier, J., Igaz, P., Burnichon, N., Amar, L., Libe, R., Badoual, C., Tissier, F., Bertherat, J., Plouin, P., Jeunemaitre, X., Gimenez‐Roqueplo, A., Frezza, C., Pollard, P., Gottlieb, E., Ge, L., Shenoy, S., Lefkowitz, R., DeFea, K., Glunde, K., Shah, T., Winnard, P., Raman, V., Takagi, T., Vesuna, F., Artemov, D., Bhujwalla, Z., Heintzman, N., Stuart, R., Hon, G., Fu, Y., Ching, C., Hawkins, R., Barrera, L., Calcar, S., Qu, C., Ching, K., Wang, W., Weng, Z., Green, R., Crawford, G., Ren, B., Heintzman, N., Hon, G., Hawkins, R., Kheradpour, P., Stark, A., Harp, L., Ye, Z., Lee, L., Stuart, R., Ching, C., Ching, K., Antosiewicz‐Bourget, J., Liu, H., Zhang, X., Green, R., Lobanenkov, V., Stewart, R., Thomson, J., Crawford, G., Kellis, M., Hon, G., Hawkins, R., Ren, B., Ji, X., Li, W., Song, J., Wei, L., Liu, X., Kaelin, W., Kaelin, W., Ratcliffe, P., Kang, J., Shi, Y., Xiang, B., Qu, B., Su, W., Zhu, M., Zhang, M., Bao, G., Wang, F., Zhang, X., Yang, R., Fan, F., Chen, X., Pei, G., Ma, L., Kenny, F., Hui, R., Musgrove, E., Gee, J., Blamey, R., Nicholson, R., Sutherland, R., Robertson, J., Korpershoek, E., Favier, J., Gaal, J., Burnichon, N., Gessel, B., Oudijk, L., Badoual, C., Gadessaud, N., Venisse, A., Bayley, J., Dooren, M., Herder, W., Tissier, F., Plouin, P., Nederveen, F., Dinjens, W., Gimenez‐Roqueplo, A., Krijger, R., Lefkowitz, R., Shenoy, S., Lehtonen, H., Kiuru, M., Ylisaukko‐Oja, S., Salovaara, R., Herva, R., Koivisto, P., Vierimaa, O., Aittomaki, K., Pukkala, E., Launonen, V., Aaltonen, L., Liu, L., Yang, M., Kang, R., Wang, Z., Zhao, Y., Yu, Y., Xie, M., Yin, X., Livesey, K., Lotze, M., Tang, D., Cao, L., Locasale, J., Lofstedt, T., Fredlund, E., Noguera, R., Navarro, S., Holmquist‐Mengelbier, L., Beckman, S., Pahlman, S., Axelson, H., Lundgren, K., Tobin, N., Lehn, S., Stal, O., Ryden, L., Jirstrom, K., Landberg, G., MacKenzie, E., Selak, M., Tennant, D., Payne, L., Crosby, S., Frederiksen, C., Watson, D., Gottlieb, E., Madhu, B., Waterton, J., Griffiths, J., Ryan, A., Robinson, S., Massie, C., Adryan, B., Barbosa‐Morais, N., Lynch, A., Tran, M., Neal, D., Mills, I., Maxwell, P., Wiesener, M., Chang, G., Clifford, S., Vaux, E., Cockman, M., Wykoff, C., Pugh, C., Maher, E., Ratcliffe, P., Metallo, C., Gameiro, P., Bell, E., Mattaini, K., Yang, J., Hiller, K., Jewell, C., Johnson, Z., Irvine, D., Guarente, L., Kelleher, J., Vander Heiden, M., Iliopoulos, O., Stephanopoulos, G., Park, C., Kim, Y., Shim, M., Lee, Y., Perroud, B., Lee, J., Valkova, N., Dhirapong, A., Lin, P., Fiehn, O., Kultz, D., Weiss, R., Piantadosi, C., Suliman, H., Raimundo, N., Baysal, B., Shadel, G., Rankin, E., Biju, M., Liu, Q., Unger, T., Rha, J., Johnson, R., Simon, M., Keith, B., Haase, V., Rosano, L., Cianfrocca, R., Masi, S., Spinella, F., Castro, V., Biroccio, A., Salvati, E., Nicotra, M., Natali, P., Bagnato, A., Schmidt, D., Wilson, M., Spyrou, C., Brown, G., Hadfield, J., Odom, D., Schwab, M., Scott, M., Rouzic, E., Perianin, A., Pierotti, V., Enslen, H., Benichou, S., Marullo, S., Benmerah, A., Seagroves, T., Ryan, H., Lu, H., Wouters, B., Knapp, M., Thibault, P., Laderoute, K., Johnson, R., Semenza, G., Semenza, G., Semenza, G., Semenza, G., Semenza, G., Shenoy, S., Han, S., Zhao, Y., Hara, M., Oliver, T., Cao, Y., Dewhirst, M., Smyth, G., Starmans, M., Chu, K., Haider, S., Nguyen, F., Seigneuric, R., Magagnin, M., Koritzinsky, M., Kasprzyk, A., Boutros, P., Wouters, B., Lambin, P., Teahan, O., Bevan, C., Waxman, J., Keun, H., Temes, E., Martin‐Puig, S., Acosta‐Iborra, B., Castellanos, M., Feijoo‐Cuaresma, M., Olmos, G., Aragones, J., Landazuri, M., Tomlinson, I., Alam, N., Rowan, A., Barclay, E., Jaeger, E., Kelsell, D., Leigh, I., Gorman, P., Lamlum, H., Rahman, S., Roylance, R., Olpin, S., Bevan, S., Barker, K., Hearle, N., Houlston, R., Kiuru, M., Lehtonen, R., Karhu, A., Vilkki, S., Tong, X., Zhao, F., Thompson, C., Vanharanta, S., Pollard, P., Lehtonen, H., Laiho, P., Sjoberg, J., Leminen, A., Aittomaki, K., Arola, J., Kruhoffer, M., Orntoft, T., Tomlinson, I., Kiuru, M., Arango, D., Aaltonen, L., Wallace, T., Prueitt, R., Yi, M., Howe, T., Gillespie, J., Yfantis, H., Stephens, R., Caporaso, N., Loffredo, C., Ambs, S., Wang, P., Wu, Y., Ge, X., Ma, L., Pei, G., Wang, Z., Zang, C., Rosenfeld, J., Schones, D., Barski, A., Cuddapah, S., Cui, K., Roh, T., Peng, W., Zhang, M., Zhao, K., Wang, J., Hevi, S., Kurash, J., Lei, H., Gay, F., Bajko, J., Su, H., Sun, W., Chang, H., Xu, G., Gaudet, F., Li, E., Chen, T., Wenger, R., Wu, H., Southam, A., Hines, A., Viant, M., Xia, X., Kung, A., Xia, X., Lemieux, M., Li, W., Carroll, J., Brown, M., Liu, X., Kung, A., Yoo, H., Antoniewicz, M., Stephanopoulos, G., Kelleher, J., Zhang, Y., Liu, T., Meyer, C., Eeckhoute, J., Johnson, D., Bernstein, B., Nussbaum, C., Myers, R., Brown, M., Li, W., Liu, X., Zheng, S., Stevens, V., Wiklund, F., Isaacs, S., Sun, J., Smith, S., Pruett, K., Wiley, K., Kim, S., Zhu, Y., Zhang, Z., Hsu, F., Turner, A., Johansson, J., Liu, W., Kim, J., Chang, B., Duggan, D., Carpten, J., & Rodriguez, C. (2014). Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer. The EMBO Journal, 33(12), 1365-1382..
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  • Restrictions:
  • This image was published the terms of the Creative Commons Attribution (CC BY) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Permission is not required for this kind of use.
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Vincent Zecchini, Basetti Madhu, Roslin Russell, Nelma Pértega‐Gomes, Anne Warren, Edoardo Gaude, Joana Borlido, Rory Stark, Heather Ireland‐Zecchini, Roheet Rao, Helen Scott, Joan Boren, Charlie Massie, Mohammad Asim, Kevin Brindle, John Griffiths, Christian Frezza, David E Neal, Ian G Mills
  • Article Copyright Year:
  • 2014
  • Publication Volume:
  • 33
  • Publication Issue:
  • 12
  • Publication Date:
  • 06/17/2014
  • DOI:

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