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  • Description:
  • Effect of exogenous bacterial PLD and phosphatidic acid on TNFα/CHX‐induced cell death. ECV304 cells were treated with increasing concentrations of (A) bacterial scPLD, (B) di‐C16‐PA (C) di‐C8‐PA or 100 μM di‐C8‐PA plus 25 μM propranolol, for 30 min prior to treatment with or without 20 ng/ml TNFα plus 10 μg/ml CHX, for 24 h. At the end of the incubation period, cell viability was measured by the MTT assay. Results are expressed relative to cell survival measured in the absence of TNFα/CHX taken as 100. They are means ± S.E. of three separate experiments performed with six replicates. ∗ significantly different from cell survival without scPLD or PA, P < 0.05. † significantly different from 100 μM di‐C8 PA alone, P < 0.05.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2015 Federation of European Biochemical Societies
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 556 x 463
  • Image File Size:
  • 53.6 KB
  • Creator:
  • Helene Birbes, Caroline Zeiller, Hiba Komati, Georges Némoz, Michel Lagarde, Annie-France Prigent
  • Credit:
  • Birbes, H., Zeiller, C., Komati, H., Némoz, G., Lagarde, M., Prigent, A.-F., Wallach, D., Muppidi, J. R., Tschopp, J., Siegel, R. M., Varfolomeev, E. E., Ashkenazi, A., Nolop, K. B., Ryan, U. S., Hannun, Y. A., Baichwal, V. R., Baeuerle, P. A., White, E., Sabbatini, P., Debbas, M., Wold, W. S. M., Kusher, D. I., Gooding, L. R., Miura, M., Friedlander, R. M., Yuan, J., Dbaibo, G. S., El-Assaad, W., Krikorian, A., Liu, B., Diab, K., Idriss, N. Z., El-Sabban, M., Driscoll, T. A., Perry, D. K., Hannun, Y. A., Luberto, C., Hassler, D. F., Signorelli, P., Okamoto, Y., Sawai, H., Boros, E., Hazen-Martin, D. J., Obeid, L. M., Hannun, Y. A., Smith, G. K., Xu, J., Yeh, C.-H., Chen, S., He, L., Sensi, S. L., Canzoniero, L. M., Choi, D. W., Hsu, C. Y., & Foster, D. A., Xu, L., Nozawa, Y., McDermott, M., Wakelam, M. J. O., Morris, A. J., Kasai, T., Ohguchi, K., Nakashima, S., Ito, Y., Naganawa, T., Kondo, N., Nozawa, Y., Kang, J. H., Shin, I., Han, J. S., Zhong, M., Joseph, T., Jackson, D., Beychenok, S., & Foster, D. A., Yoshimura, S., Sakai, H., Ohguchi, K., Nakashima, S., Banno, Y., Nishimura, Y., Sakai, N., Nozawa, Y., Iwasaki-Bessho, Y., Banno, Y., Yoshimura, S., Ito, Y., Kitajima, Y., Nozawa, Y., Zheng, X. L., Gui, Y., Du, G., Frohman, M. A., Peng, D. Q., Lee, S.-Y., Oh, J.-Y., Lee, M.-J., Jang, M.-J., Park, H.-Y., Kim, J.-W., Min, D. S., Park, Y.-M., Chang, Y.-C., Bae, Y.-S., Kwak, J.-Y., Zhong, M., Shen, Y., Zheng, Y., Joseph, T., Jackson, D., & Foster, D. A., Yamada, M., Banno, Y., Takuwa, Y., Koda, M., Hara, A., Nozawa, Y., Mosmann, T., Bligh, E. G., Dyer, W. J., Dbaibo, G. S., Pushkareva, M. Y., Rachid, R. A., Alter, N., Smyth, M. J., Obeid, L. M., Hannun, Y. A., Birbes, H., El Bawab, S., Hannun, Y. A., Obeid, L. M., Diaz, O., Mebarek-Azzam, S., Benzaria, A., Dubois, M., Lagarde, M., Némoz, G., Prigent, A. F., Fang, Y., Park, I. H., Wu, A. L., Du, G., Huang, P., Frohman, M. A., Walker, S. J., Brown, H. A., Chen, J., Powner, D. J., Payne, R. M., Pettitt, T. R., Giudici, M. L., Irvine, R. F., Wakelam, M. J., Karsan, A., Yee, E., Harlan, J. M., Cooper, J. T., Stroka, D. M., Brostjan, C., Palmetshofer, A., Bach, F. H., Ferran, C., Venable, M. E., Bielawska, A., Obeid, L. M., Gomez-Munoz, A., Martin, A., O’Brien, L., Brindley, D. N., Yamakawa, H., Banno, Y., Nakashima, S., Sawada, M., Yamada, J., Yoshimura, S., Nishimura, Y., Nozawa, Y., Sakai, N., Taha, T. A., Hannun, Y. A., Obeid, L. M., Delon, C., Manifava, M., Wood, E., Thompson, D., Krugmann, S., Pyne, S., Ktistakis, N. T., Fang, Y., Vilella-Bach, M., Bachmann, R., Flanigan, A., Chen, J., Chen, Y., Rodrik, V., & Foster, D. A. (2006). Phospholipase D protects ECV304 cells against TNFα‐induced apoptosis. FEBS Letters, 580(26), 6224-6232. https://doi.org/10.1016/j.febslet.2006.10.
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Helene Birbes, Caroline Zeiller, Hiba Komati, Georges Némoz, Michel Lagarde, Annie-France Prigent
  • Article Copyright Year:
  • 2006
  • Publication Volume:
  • 580
  • Publication Issue:
  • 26
  • Publication Date:
  • 11/13/2006
  • DOI:

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