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  • Description:
  • Effect of simvastatin on MAP changes induced by acetylcholine and sodium nitroprusside in a model of experimental periodontitis. Treatment with simvastatin (10 mg/kg/d, p.o.) or vehicle (water, 0.1 mL/kg/d, p.o.) was initiated on the eighth day after the ligature or sham procedure, and the rats were prepared on the 14th day for MAP recording. Increasing doses of acetylcholine (A) and sodium nitroprusside (B) were injected (i.v.) and changes in MAP were recorded. Each bar represents the mean of eight animals, and the vertical lines represent the SEM. *p < 0.05 compared to the sham vehicle‐treated group, #p < 0.05 compared to the ligature vehicle‐treated group. MAP, mean arterial pressure.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Copyright © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • x
  • Image File Size:
  • 123 KB
  • Creator:
  • W. M. Machado, A. P. Prestes, T. P. Costa, R. T. Mendes, L. R. Olchanheski, R. Sordi, M. F. Otuki, G. M. Fávero, J. C. R. Vellosa, F. A. Santos, D. Fernandes
  • Credit:
  • Machado, W., Prestes, A., Costa, T., Mendes, R., Olchanheski, L., Sordi, R., Otuki, M., Fávero, G., Vellosa, J., Santos, F., Fernandes, D., Dahlof, B., Seymour, G., Ford, P., Cullinan, M., Leishman, S., West, M., Yamazaki, K., Libby, P., Ridker, P., Maseri, A., Page, R., Kornman, K., Cochran, D., Tonetti, M., D'Aiuto, F., Nibali, L., Higashi, Y., Goto, C., Hidaka, T., Deanfield, J., Halcox, J., Rabelink, T., Furstermann, U., Mugge, A., Alheid, U., Haverich, A., Frolich, J., Higashi, Y., Goto, C., Jitsuiki, D., Amar, S., Gokce, N., Morgan, S., Loukideli, M., Dyke, T., Vita, J., Davignon, J., Halcox, J., Deanfield, J., Banach, M., Mikihailidis, D., Kjeldsen, S., Rysz, J., Nissen, S., Tuzcu, E., Schoenhagen, P., Wierzbicki, A., Poston, R., Ferro, A., Koh, K., Ceriello, A., Assaloni, R., Ros, R., Crisby, M., Carlson, M., Winblad, B., Negredo, E., Clotet, B., Puig, J., Kim, J., Lee, E., Lee, E., Wu, Z., Liu, C., Zang, G., Rovin, S., Costich, E., Fleming, J., Gordon, H., Alvarez de Sotomayor, M., Vega, S., Mingorance, C., Marhuenda, E., Herrera, M., Knight, S., Yuan, J., Roy, S., Imig, J., Brito, L., Dalbó, S., Striechen, T., Herrera, B., Martins‐Porto, R., Campi, P., Meulman, T., Peruzzo, D., Stipp, R., Dalcico, R., Menezes, A., Deocleciano, O., Vaziri, H., Naserhojjati‐Roodsari, R., Tahsili‐Fahadan, N., Mendes, R., Sordi, R., Olchanheski, L., Staal, A., Frith, J., French, M., Mundy, G., Garrett, R., Harris, S., LaraJanz, F., Favero, G., Bohatch, M., Aguiar Debes, A., Bydlowski, S., Seto, H., Ohba, H., Tokunaga, K., Hama, H., Horibe, M., Nagata, T., Schenkein, H., Loos, B., Danesh, J., Kaptoge, S., Mann, A., Ridker, P., Rifai, N., Rose, L., Buring, J., Cook, N., Mihaylova, B., Emberson, J., Blackwell, L., Monteiro, A., Jardini, M., Alves, S., Giampaoli, V., Aubin, E., Aird, W., Gitlin, J., Loftin, C., Mendes, R., Stanczyk, C., Sordi, R., Otuki, M., Santos, F., Fernandes, D., Trelle, S., Reichenbach, S., & Wandel, S. (2014). The effect of simvastatin on systemic inflammation and endothelial dysfunction induced by periodontitis. Journal of Periodontal Research, 49(5), 634-641..
  • Collection:
  • Keywords:
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  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • W. M. Machado, A. P. Prestes, T. P. Costa, R. T. Mendes, L. R. Olchanheski, R. Sordi, M. F. Otuki, G. M. Fávero, J. C. R. Vellosa, F. A. Santos, D. Fernandes
  • Article Copyright Year:
  • 2014
  • Publication Volume:
  • 49
  • Publication Issue:
  • 5
  • Publication Date:
  • 10/01/2014
  • DOI:

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