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  • Description:
  • Inhibition of both the anticoagulant and cytoprotective function of (A)PC significantly reduces survival after LD100 and LD65 infection with B. pseudomallei whereas selective inhibition of the anticoagulant effects of APC is without effect. Mice were treated with MPC1609 (inhibiting both the anticoagulant and cytoprotective functions of PC), MAPC1591 (inhibiting only the anticoagulant functions of PC) or MCO1716 (control) and were infected intranasally with 750 CFU (A; LD100) or 250 CFU (B; LD65) of B. pseudomallei. Mortality was assessed every 4–6 h, n = 14–20 mice per group. Comparison between groups was done by using Kaplan–Meier analysis followed by log rank tests.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Copyright © 2013 International Society on Thrombosis and Haemostasis
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 1103 x 375
  • Image File Size:
  • 87.7 KB
  • Creator:
  • L. M. Kager, W. J. Wiersinga, J. J. Roelofs, J. C. M. Meijers, S. S. Zeerleder, C. T. Esmon, C. 't Veer, T. Poll
  • Credit:
  • Kager, L., Wiersinga, W., Roelofs, J., Meijers, J., Zeerleder, S., Esmon, C., 't Veer, C., Poll, T., Esmon, C., Mosnier, L., Zlokovic, B., Griffin, J., Danese, S., Vetrano, S., Zhang, L., Poplis, V., Castellino, F., Sammani, S., Moreno‐Vinasco, L., Mirzapoiazova, T., Singleton, P., Chiang, E., Evenoski, C., Wang, T., Mathew, B., Husain, A., Moitra, J., Sun, X., Nunez, L., Jacobson, J., Dudek, S., Natarajan, V., Garcia, J., Spiegel, S., Milstien, S., Feistritzer, C., Riewald, M., Finigan, J., Dudek, S., Singleton, P., Chiang, E., Jacobson, J., Camp, S., Ye, S., Garcia, J., McVerry, B., Peng, X., Hassoun, P., Sammani, S., Simon, B., Garcia, J., Peng, X., Hassoun, P., Sammani, S., McVerry, B., Burne, M., Rabb, H., Pearse, D., Tuder, R., Garcia, J., Xu, J., Zhang, X., Pelayo, R., Monestier, M., Ammollo, C., Semeraro, F., Taylor, F., Esmon, N., Lupu, F., Esmon, C., Shaw, A., Vail, G., Haney, D., Xie, J., Williams, M., Macias, W., Nelson, D., Fisher, C., Yan, S., Liaw, P., Esmon, C., Kahnamoui, K., Schmidt, S., Kahnamoui, S., Ferrell, G., Beaudin, S., Julian, J., Weitz, J., Crowther, M., Loeb, M., Cook, D., Levi, M., Dorffler‐Melly, J., Reitsma, P., Buller, H., Florquin, S., Poll, T., Carmeliet, P., Lay, A., Donahue, D., Tsai, M., Castellino, F., Schouten, M., 't Veer, C., Levi, M., Esmon, C., Poll, T., Schouten, M., Boer, J., Sluijs, K., Roelofs, J., 't Veer, C., Levi, M., Esmon, C., Poll, T., Xu, J., Ji, Y., Zhang, X., Drake, M., Esmon, C., Kager, L., Wiersinga, W., Roelofs, J., Meijers, J., Levi, M., 't Veer, C., Poll, T., Kager, L., Wiersinga, W., Roelofs, J., Meijers, J., Levi, M., 't Veer, C., Poll, T., Wiersinga, W., Wieland, C., Dessing, M., Chantratita, N., Cheng, A., Limmathurotsakul, D., Chierakul, W., Leendertse, M., Florquin, S., Vos, A., White, N., Dondorp, A., Day, N., Peacock, S., Poll, T., Meumann, E., Cheng, A., Ward, L., Currie, B., White, N., Wiersinga, W., Poll, T., White, N., Day, N., Peacock, S., Wiersinga, W., Meijers, J., Levi, M., 't Veer, C., Day, N., Peacock, S., Poll, T., LaRosa, S., Opal, S., Utterback, B., Yan, S., Helterbrand, J., Simpson, A., Chaowagul, W., White, N., Fisher, C., Sluis, G., Niers, T., Esmon, C., Tigchelaar, W., Richel, D., Buller, H., Noorden, C., Spek, C., Awad, A., Ye, H., Huang, L., Li, L., Foss, F., Macdonald, T., Lynch, K., Okusa, M., Zeerleder, S., Zwart, B., te Velthuis, H., Manoe, R., Bulder, I., Rensink, I., Aarden, L., Windt, G., Schouten, M., Zeerleder, S., Florquin, S., Poll, T., Bae, J., Yang, L., Manithody, C., Rezaie, A., Kerschen, E., Hernandez, I., Zogg, M., Jia, S., Hessner, M., Fernandez, J., Griffin, J., Huettner, C., Castellino, F., & Weiler, H., Zeerleder, S., Zwart, B., Wuillemin, W., Aarden, L., Groeneveld, A., Caliezi, C., Nieuwenhuijze, A., Mierlo, G., Eerenberg, A., Lammle, B., Hack, C., Ranieri, V., Thompson, B., Barie, P., Dhainaut, J., Douglas, I., Finfer, S., Gardlund, B., Marshall, J., Rhodes, A., Artigas, A., Payen, D., Tenhunen, J., Al‐Khalidi, H., Thompson, V., Janes, J., Macias, W., Vangerow, B., Williams, M., Levi, M., Poll, T., Ruf, W., Kerschen, E., Fernandez, J., Cooley, B., Yang, X., Sood, R., Mosnier, L., Castellino, F., Mackman, N., Griffin, J., & Weiler, H. (2013). Endogenous protein C has a protective role during Gram‐negative pneumosepsis (melioidosis) Journal of Thrombosis and Haemostasis, 11(2), 282-292..
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • L. M. Kager, W. J. Wiersinga, J. J. Roelofs, J. C. M. Meijers, S. S. Zeerleder, C. T. Esmon, C. 't Veer, T. Poll
  • Article Copyright Year:
  • 2013
  • Publication Volume:
  • 11
  • Publication Issue:
  • 2
  • Publication Date:
  • 02/01/2013
  • DOI:

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