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  • Description:
  • Inhibition of both the anticoagulant and cytoprotective function of (A)PC facilitates bacterial growth and dissemination. Mice were treated with MPC1609 (inhibiting both the anticoagulant and cytoprotective functions of PC; white bars), MAPC1591 (inhibiting only the anticoagulant functions of PC; striped bars) or MCO1716 (control; black bars) and infected intranasally with 750 CFU (LD100) or 250 CFU (LD65) of B. pseudomallei. Mice were sacrificed after 24, 48 or 72 h and bacterial loads were measured in lung homogenates (A), BALF (B), whole blood (C) and liver homogenates (D). Data are expressed as bars with means ± SEM; n = 7–8 mice per group for each time‐point. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. MCO1716 (Mann–Whitney U test). BALF, bronchoalveolar lavage fluid; ND, not determined.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Copyright © 2013 International Society on Thrombosis and Haemostasis
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 1103 x 869
  • Image File Size:
  • 172 KB
  • Creator:
  • L. M. Kager, W. J. Wiersinga, J. J. Roelofs, J. C. M. Meijers, S. S. Zeerleder, C. T. Esmon, C. 't Veer, T. Poll
  • Credit:
  • Kager, L., Wiersinga, W., Roelofs, J., Meijers, J., Zeerleder, S., Esmon, C., 't Veer, C., Poll, T., Esmon, C., Mosnier, L., Zlokovic, B., Griffin, J., Danese, S., Vetrano, S., Zhang, L., Poplis, V., Castellino, F., Sammani, S., Moreno‐Vinasco, L., Mirzapoiazova, T., Singleton, P., Chiang, E., Evenoski, C., Wang, T., Mathew, B., Husain, A., Moitra, J., Sun, X., Nunez, L., Jacobson, J., Dudek, S., Natarajan, V., Garcia, J., Spiegel, S., Milstien, S., Feistritzer, C., Riewald, M., Finigan, J., Dudek, S., Singleton, P., Chiang, E., Jacobson, J., Camp, S., Ye, S., Garcia, J., McVerry, B., Peng, X., Hassoun, P., Sammani, S., Simon, B., Garcia, J., Peng, X., Hassoun, P., Sammani, S., McVerry, B., Burne, M., Rabb, H., Pearse, D., Tuder, R., Garcia, J., Xu, J., Zhang, X., Pelayo, R., Monestier, M., Ammollo, C., Semeraro, F., Taylor, F., Esmon, N., Lupu, F., Esmon, C., Shaw, A., Vail, G., Haney, D., Xie, J., Williams, M., Macias, W., Nelson, D., Fisher, C., Yan, S., Liaw, P., Esmon, C., Kahnamoui, K., Schmidt, S., Kahnamoui, S., Ferrell, G., Beaudin, S., Julian, J., Weitz, J., Crowther, M., Loeb, M., Cook, D., Levi, M., Dorffler‐Melly, J., Reitsma, P., Buller, H., Florquin, S., Poll, T., Carmeliet, P., Lay, A., Donahue, D., Tsai, M., Castellino, F., Schouten, M., 't Veer, C., Levi, M., Esmon, C., Poll, T., Schouten, M., Boer, J., Sluijs, K., Roelofs, J., 't Veer, C., Levi, M., Esmon, C., Poll, T., Xu, J., Ji, Y., Zhang, X., Drake, M., Esmon, C., Kager, L., Wiersinga, W., Roelofs, J., Meijers, J., Levi, M., 't Veer, C., Poll, T., Kager, L., Wiersinga, W., Roelofs, J., Meijers, J., Levi, M., 't Veer, C., Poll, T., Wiersinga, W., Wieland, C., Dessing, M., Chantratita, N., Cheng, A., Limmathurotsakul, D., Chierakul, W., Leendertse, M., Florquin, S., Vos, A., White, N., Dondorp, A., Day, N., Peacock, S., Poll, T., Meumann, E., Cheng, A., Ward, L., Currie, B., White, N., Wiersinga, W., Poll, T., White, N., Day, N., Peacock, S., Wiersinga, W., Meijers, J., Levi, M., 't Veer, C., Day, N., Peacock, S., Poll, T., LaRosa, S., Opal, S., Utterback, B., Yan, S., Helterbrand, J., Simpson, A., Chaowagul, W., White, N., Fisher, C., Sluis, G., Niers, T., Esmon, C., Tigchelaar, W., Richel, D., Buller, H., Noorden, C., Spek, C., Awad, A., Ye, H., Huang, L., Li, L., Foss, F., Macdonald, T., Lynch, K., Okusa, M., Zeerleder, S., Zwart, B., te Velthuis, H., Manoe, R., Bulder, I., Rensink, I., Aarden, L., Windt, G., Schouten, M., Zeerleder, S., Florquin, S., Poll, T., Bae, J., Yang, L., Manithody, C., Rezaie, A., Kerschen, E., Hernandez, I., Zogg, M., Jia, S., Hessner, M., Fernandez, J., Griffin, J., Huettner, C., Castellino, F., & Weiler, H., Zeerleder, S., Zwart, B., Wuillemin, W., Aarden, L., Groeneveld, A., Caliezi, C., Nieuwenhuijze, A., Mierlo, G., Eerenberg, A., Lammle, B., Hack, C., Ranieri, V., Thompson, B., Barie, P., Dhainaut, J., Douglas, I., Finfer, S., Gardlund, B., Marshall, J., Rhodes, A., Artigas, A., Payen, D., Tenhunen, J., Al‐Khalidi, H., Thompson, V., Janes, J., Macias, W., Vangerow, B., Williams, M., Levi, M., Poll, T., Ruf, W., Kerschen, E., Fernandez, J., Cooley, B., Yang, X., Sood, R., Mosnier, L., Castellino, F., Mackman, N., Griffin, J., & Weiler, H. (2013). Endogenous protein C has a protective role during Gram‐negative pneumosepsis (melioidosis) Journal of Thrombosis and Haemostasis, 11(2), 282-292..
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • L. M. Kager, W. J. Wiersinga, J. J. Roelofs, J. C. M. Meijers, S. S. Zeerleder, C. T. Esmon, C. 't Veer, T. Poll
  • Article Copyright Year:
  • 2013
  • Publication Volume:
  • 11
  • Publication Issue:
  • 2
  • Publication Date:
  • 02/01/2013
  • DOI:

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