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  • Description:
  • Lung pathology. Mice were treated with MPC1609 (inhibiting both the anticoagulant and cytoprotective functions of PC; white bars), MAPC1591 (inhibiting only the anticoagulant functions of PC; striped bars) or MCO1716 (control; black bars) and infected intranasally with 750 CFU (LD100) or 250 CFU (LD65) of B. pseudomallei. Mice were sacrificed after 24, 48 or 72 h. (A) Lung histopathology scores determined as described in the Methods section. Representative lung tissue slides (H&E staining ×100) 72 h after LD65 infection in mice treated with MCO1716 (B), MPC1609 (C) or MAPC1591 (D). Ly6G‐positivity (expressed as % of total lung surface) (E). Representative photographs of Ly6G‐immunostaining (original magnification ×100) for granulocytes of mice treated with MCO1716 (F), MPC1609 (G) and MAPC1591 (H). Lung MPO (I), total leukocyte number in BALF (J), neutrophil number in BALF (K), total protein concentration in BALF (L), nucleosome levels in BALF (M). Data are expressed as bars with means ± SEM; n = 7–8 mice per group for each time‐point. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. MCO1716 (Mann–Whitney U‐test). BALF, bronchoalveolar lavage fluid; MPO, myeloperoxidase; ND, not determined.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Copyright © 2013 International Society on Thrombosis and Haemostasis
  • Asset Type:
  • Image
  • Asset Subtype:
  • Photo
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 1366 x 947
  • Image File Size:
  • 1.04 MB
  • Creator:
  • L. M. Kager, W. J. Wiersinga, J. J. Roelofs, J. C. M. Meijers, S. S. Zeerleder, C. T. Esmon, C. 't Veer, T. Poll
  • Credit:
  • Kager, L., Wiersinga, W., Roelofs, J., Meijers, J., Zeerleder, S., Esmon, C., 't Veer, C., Poll, T., Esmon, C., Mosnier, L., Zlokovic, B., Griffin, J., Danese, S., Vetrano, S., Zhang, L., Poplis, V., Castellino, F., Sammani, S., Moreno‐Vinasco, L., Mirzapoiazova, T., Singleton, P., Chiang, E., Evenoski, C., Wang, T., Mathew, B., Husain, A., Moitra, J., Sun, X., Nunez, L., Jacobson, J., Dudek, S., Natarajan, V., Garcia, J., Spiegel, S., Milstien, S., Feistritzer, C., Riewald, M., Finigan, J., Dudek, S., Singleton, P., Chiang, E., Jacobson, J., Camp, S., Ye, S., Garcia, J., McVerry, B., Peng, X., Hassoun, P., Sammani, S., Simon, B., Garcia, J., Peng, X., Hassoun, P., Sammani, S., McVerry, B., Burne, M., Rabb, H., Pearse, D., Tuder, R., Garcia, J., Xu, J., Zhang, X., Pelayo, R., Monestier, M., Ammollo, C., Semeraro, F., Taylor, F., Esmon, N., Lupu, F., Esmon, C., Shaw, A., Vail, G., Haney, D., Xie, J., Williams, M., Macias, W., Nelson, D., Fisher, C., Yan, S., Liaw, P., Esmon, C., Kahnamoui, K., Schmidt, S., Kahnamoui, S., Ferrell, G., Beaudin, S., Julian, J., Weitz, J., Crowther, M., Loeb, M., Cook, D., Levi, M., Dorffler‐Melly, J., Reitsma, P., Buller, H., Florquin, S., Poll, T., Carmeliet, P., Lay, A., Donahue, D., Tsai, M., Castellino, F., Schouten, M., 't Veer, C., Levi, M., Esmon, C., Poll, T., Schouten, M., Boer, J., Sluijs, K., Roelofs, J., 't Veer, C., Levi, M., Esmon, C., Poll, T., Xu, J., Ji, Y., Zhang, X., Drake, M., Esmon, C., Kager, L., Wiersinga, W., Roelofs, J., Meijers, J., Levi, M., 't Veer, C., Poll, T., Kager, L., Wiersinga, W., Roelofs, J., Meijers, J., Levi, M., 't Veer, C., Poll, T., Wiersinga, W., Wieland, C., Dessing, M., Chantratita, N., Cheng, A., Limmathurotsakul, D., Chierakul, W., Leendertse, M., Florquin, S., Vos, A., White, N., Dondorp, A., Day, N., Peacock, S., Poll, T., Meumann, E., Cheng, A., Ward, L., Currie, B., White, N., Wiersinga, W., Poll, T., White, N., Day, N., Peacock, S., Wiersinga, W., Meijers, J., Levi, M., 't Veer, C., Day, N., Peacock, S., Poll, T., LaRosa, S., Opal, S., Utterback, B., Yan, S., Helterbrand, J., Simpson, A., Chaowagul, W., White, N., Fisher, C., Sluis, G., Niers, T., Esmon, C., Tigchelaar, W., Richel, D., Buller, H., Noorden, C., Spek, C., Awad, A., Ye, H., Huang, L., Li, L., Foss, F., Macdonald, T., Lynch, K., Okusa, M., Zeerleder, S., Zwart, B., te Velthuis, H., Manoe, R., Bulder, I., Rensink, I., Aarden, L., Windt, G., Schouten, M., Zeerleder, S., Florquin, S., Poll, T., Bae, J., Yang, L., Manithody, C., Rezaie, A., Kerschen, E., Hernandez, I., Zogg, M., Jia, S., Hessner, M., Fernandez, J., Griffin, J., Huettner, C., Castellino, F., & Weiler, H., Zeerleder, S., Zwart, B., Wuillemin, W., Aarden, L., Groeneveld, A., Caliezi, C., Nieuwenhuijze, A., Mierlo, G., Eerenberg, A., Lammle, B., Hack, C., Ranieri, V., Thompson, B., Barie, P., Dhainaut, J., Douglas, I., Finfer, S., Gardlund, B., Marshall, J., Rhodes, A., Artigas, A., Payen, D., Tenhunen, J., Al‐Khalidi, H., Thompson, V., Janes, J., Macias, W., Vangerow, B., Williams, M., Levi, M., Poll, T., Ruf, W., Kerschen, E., Fernandez, J., Cooley, B., Yang, X., Sood, R., Mosnier, L., Castellino, F., Mackman, N., Griffin, J., & Weiler, H. (2013). Endogenous protein C has a protective role during Gram‐negative pneumosepsis (melioidosis) Journal of Thrombosis and Haemostasis, 11(2), 282-292..
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • L. M. Kager, W. J. Wiersinga, J. J. Roelofs, J. C. M. Meijers, S. S. Zeerleder, C. T. Esmon, C. 't Veer, T. Poll
  • Article Copyright Year:
  • 2013
  • Publication Volume:
  • 11
  • Publication Issue:
  • 2
  • Publication Date:
  • 02/01/2013
  • DOI:

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