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  • Description:
  • Treatment with SEW‐2871, a selective sphingosine‐1‐phosphate receptor‐1 (S1P1) agonist, does not reverse MPC1609 effects. Mice were treated with MPC1609 (inhibiting both the anticoagulant and cytoprotective functions of PC; white bars) or MCO1716 (control; black bars) with or without the selective S1P1 agonist SEW2871 (with MPC1609, white‐hatched bars; with MCO1716, grey‐hatched bars). All mice were infected intranasally with 750 CFU (LD100) of B. pseudomallei and sacrificed after 48 h. Bacterial loads in lungs (A), BALF (B), blood (C) and liver (D). Thrombin‐antithrombin complexes (TATc) in lung homogenates (E), total protein in BALF (F) and lung (G) and plasma (H) IL‐6, a proinflammatory cytokine, while, again, no differences were seen between mice treated with SEW‐2871 and control mice. Data are expressed as bars with means ± SEM; n = 8 mice per group. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. MCO1716, #P < 0.05 vs. MPC1609 (Mann–Whitney U‐test). BALF, bronchoalveolar lavage fluid; ND, not determined; S1P1, sphingosine‐1‐phosphate receptor‐1; TATc, thrombin‐antithrombin complexes.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Copyright © 2013 International Society on Thrombosis and Haemostasis
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 1367 x 481
  • Image File Size:
  • 116 KB
  • Creator:
  • L. M. Kager, W. J. Wiersinga, J. J. Roelofs, J. C. M. Meijers, S. S. Zeerleder, C. T. Esmon, C. 't Veer, T. Poll
  • Credit:
  • Kager, L., Wiersinga, W., Roelofs, J., Meijers, J., Zeerleder, S., Esmon, C., 't Veer, C., Poll, T., Esmon, C., Mosnier, L., Zlokovic, B., Griffin, J., Danese, S., Vetrano, S., Zhang, L., Poplis, V., Castellino, F., Sammani, S., Moreno‐Vinasco, L., Mirzapoiazova, T., Singleton, P., Chiang, E., Evenoski, C., Wang, T., Mathew, B., Husain, A., Moitra, J., Sun, X., Nunez, L., Jacobson, J., Dudek, S., Natarajan, V., Garcia, J., Spiegel, S., Milstien, S., Feistritzer, C., Riewald, M., Finigan, J., Dudek, S., Singleton, P., Chiang, E., Jacobson, J., Camp, S., Ye, S., Garcia, J., McVerry, B., Peng, X., Hassoun, P., Sammani, S., Simon, B., Garcia, J., Peng, X., Hassoun, P., Sammani, S., McVerry, B., Burne, M., Rabb, H., Pearse, D., Tuder, R., Garcia, J., Xu, J., Zhang, X., Pelayo, R., Monestier, M., Ammollo, C., Semeraro, F., Taylor, F., Esmon, N., Lupu, F., Esmon, C., Shaw, A., Vail, G., Haney, D., Xie, J., Williams, M., Macias, W., Nelson, D., Fisher, C., Yan, S., Liaw, P., Esmon, C., Kahnamoui, K., Schmidt, S., Kahnamoui, S., Ferrell, G., Beaudin, S., Julian, J., Weitz, J., Crowther, M., Loeb, M., Cook, D., Levi, M., Dorffler‐Melly, J., Reitsma, P., Buller, H., Florquin, S., Poll, T., Carmeliet, P., Lay, A., Donahue, D., Tsai, M., Castellino, F., Schouten, M., 't Veer, C., Levi, M., Esmon, C., Poll, T., Schouten, M., Boer, J., Sluijs, K., Roelofs, J., 't Veer, C., Levi, M., Esmon, C., Poll, T., Xu, J., Ji, Y., Zhang, X., Drake, M., Esmon, C., Kager, L., Wiersinga, W., Roelofs, J., Meijers, J., Levi, M., 't Veer, C., Poll, T., Kager, L., Wiersinga, W., Roelofs, J., Meijers, J., Levi, M., 't Veer, C., Poll, T., Wiersinga, W., Wieland, C., Dessing, M., Chantratita, N., Cheng, A., Limmathurotsakul, D., Chierakul, W., Leendertse, M., Florquin, S., Vos, A., White, N., Dondorp, A., Day, N., Peacock, S., Poll, T., Meumann, E., Cheng, A., Ward, L., Currie, B., White, N., Wiersinga, W., Poll, T., White, N., Day, N., Peacock, S., Wiersinga, W., Meijers, J., Levi, M., 't Veer, C., Day, N., Peacock, S., Poll, T., LaRosa, S., Opal, S., Utterback, B., Yan, S., Helterbrand, J., Simpson, A., Chaowagul, W., White, N., Fisher, C., Sluis, G., Niers, T., Esmon, C., Tigchelaar, W., Richel, D., Buller, H., Noorden, C., Spek, C., Awad, A., Ye, H., Huang, L., Li, L., Foss, F., Macdonald, T., Lynch, K., Okusa, M., Zeerleder, S., Zwart, B., te Velthuis, H., Manoe, R., Bulder, I., Rensink, I., Aarden, L., Windt, G., Schouten, M., Zeerleder, S., Florquin, S., Poll, T., Bae, J., Yang, L., Manithody, C., Rezaie, A., Kerschen, E., Hernandez, I., Zogg, M., Jia, S., Hessner, M., Fernandez, J., Griffin, J., Huettner, C., Castellino, F., & Weiler, H., Zeerleder, S., Zwart, B., Wuillemin, W., Aarden, L., Groeneveld, A., Caliezi, C., Nieuwenhuijze, A., Mierlo, G., Eerenberg, A., Lammle, B., Hack, C., Ranieri, V., Thompson, B., Barie, P., Dhainaut, J., Douglas, I., Finfer, S., Gardlund, B., Marshall, J., Rhodes, A., Artigas, A., Payen, D., Tenhunen, J., Al‐Khalidi, H., Thompson, V., Janes, J., Macias, W., Vangerow, B., Williams, M., Levi, M., Poll, T., Ruf, W., Kerschen, E., Fernandez, J., Cooley, B., Yang, X., Sood, R., Mosnier, L., Castellino, F., Mackman, N., Griffin, J., & Weiler, H. (2013). Endogenous protein C has a protective role during Gram‐negative pneumosepsis (melioidosis) Journal of Thrombosis and Haemostasis, 11(2), 282-292..
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • L. M. Kager, W. J. Wiersinga, J. J. Roelofs, J. C. M. Meijers, S. S. Zeerleder, C. T. Esmon, C. 't Veer, T. Poll
  • Article Copyright Year:
  • 2013
  • Publication Volume:
  • 11
  • Publication Issue:
  • 2
  • Publication Date:
  • 02/01/2013
  • DOI:

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