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  • Description:
  • The organization of the GPIb‐IX complex, viewed from the extracellular space towards the membrane, is summarized in a sketch for easy visualization and comprehension. (A) The membrane‐proximal extracellular and transmembrane domains of GPIb‐IX have been modeled in ribbon diagrams, with its side view shown on the left and top view in the middle (adapted from ). Ibα, Ibβ and IX subunits are shown in black, green and red color, respectively. The general locations of N‐ and C‐capping regions and convex loops in IXE are marked. The side chains of Tyr106 in Ibβ are shown as ball‐and‐sticks in teal, and those of Pro74 in Ibβ as spheres in marine. The juxtamembrane Ibα‐Ibβ disulfide bonds are shown in orange. These domains are shown in (B) as sketches of the same color. The transmembrane domains are represented by dashed coils. The extracellular domains are drawn in solid curves, with convex loops (a, b, c) marked in each domain. Positions of Tyr106 and Pro74 are marked with a star and dot, respectively.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Copyright © 2014 International Society on Thrombosis and Haemostasis
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 655 x 678
  • Image File Size:
  • 207 KB
  • Creator:
  • L. Zhou, W. Yang, R. Li
  • Credit:
  • Zhou, L., Yang, W., Li, R., Berndt, M., Gregory, C., Kabral, A., Zola, H., Fournier, D., Castaldi, P., Luo, S.-Z., Mo, X., Afshar‐Kharghan, V., Srinivasan, S., Lopez, J., Li, R., Li, R., Emsley, J., Huizinga, E., Tsuji, S., Romijn, R., Schiphorst, M., Groot, P., Sixma, J., Gros, P., Dumas, J., Kumar, R., Seehra, J., Somers, W., Mosyak, L., Celikel, R., McClintock, R., Roberts, J., Mendolicchio, G., Ware, J., Varughese, K., Ruggeri, Z., Lopez, J., Leung, B., Reynolds, C., Li, C., Fox, J., Luo, S.-Z., Mo, X., López, J., Li, R., Mo, X., Lu, N., Padilla, A., López, J., Li, R., Berndt, M., Andrews, R., Kato, K., Martinez, C., Russell, S., Nurden, P., Nurden, A., Fiering, S., Ware, J., Strassel, C., Nonne, C., Eckly, A., David, T., Leon, C., Freund, M., Cazenave, J., Gachet, C., Lanza, F., Bodnar, R., Xi, X., Li, Z., Berndt, M., & Du, X., Ravanat, C., Strassel, C., Hechler, B., Schuhler, S., Chicanne, G., Payrastre, B., Gachet, C., Lanza, F., Maurer, E., Tang, C., Schaff, M., Bourdon, C., Receveur, N., Ravanat, C., Eckly, A., Hechler, B., Gachet, C., Lanza, F., Mangin, P., Luo, S., Li, R., Kenny, D., Morateck, P., Gill, J., Montgomery, R., Mo, X., Nguyen, N., McEwan, P., Zheng, X., Lopez, J., Emsley, J., Li, R., McEwan, P., Yang, W., Carr, K., Mo, X., Zheng, X., Li, R., Emsley, J., Lopez, J., Weisman, S., Sanan, D., Sih, T., Chambers, M., Li, C., Mo, X., Luo, S.-Z., López, J., Li, R., Dong, J., Gao, S., Lopez, J., Mo, X., Liu, L., Lopez, J., Li, R., Staron, M., Wu, S., Hong, F., Stojanovic, A., & Du, X., Bona, R., Liu, B., Li, Z., Wei, P., Liu, X., Hu, M., Zuo, L., Kai, M., Wang, R., Luo, S., Finch, C., Lyle, V., Cunningham, D., Miller, J., Perrault, C., Mangin, P., Santer, M., Baas, M., Moog, S., Cranmer, S., Pikovski, I., Williamson, D., Jackson, S., Cazenave, J., Lanza, F., Dai, K., Bodnar, R., Berndt, M., & Du, X. (2014). Analysis of inter‐subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib‐IX complex. Journal of Thrombosis and Haemostasis, 12(1), 82-89..
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • L. Zhou, W. Yang, R. Li
  • Article Copyright Year:
  • 2014
  • Publication Volume:
  • 12
  • Publication Issue:
  • 1
  • Publication Date:
  • 01/01/2014
  • DOI:

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