Asset Details

  • Description:
  • A proposed mechanism of cell protection by tissue plasminogen activator (tPA) antagonism. The proteolytic cleavage of a putative target (e.g., NMDA receptor) by tPA induces cell apoptosis and/or cell death. Aprotinin, FPRck (Phe‐Pro‐Arg‐CH2Cl), and EGRck (Glu‐Gly‐Arg‐CH2Cl) directly antagonize the proteolytic activity of tPA, whereas EACA (ɛ‐aminocaproic acid) inhibits the binding of tPA to lysine residues on the cell surface.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2009 The Authors. Journal compilation © 2009 The Acta Anaesthesiologica Scandinavica Foundation
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 321 x 272
  • Image File Size:
  • 14.6 KB
  • Creator:
  • H.‐Y. SUN, F. SZLAM, J. H. LEVY, M. E. CSETE, K. A. TANAKA
  • Credit:
  • Sun, H.-Y., Szlam, F., Levy, J. H., Csete, M. E., & Tanaka, K. A. (2009). Antifibrinolytic agents reduce tissue plasminogen activator‐mediated neuronal toxicity in vitro. Acta Anaesthesiologica Scandinavica, 53(3), 325-331. https://doi.org/10.1111/j.1399-6576.2008.01858.x.
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • H.‐Y. SUN, F. SZLAM, J. H. LEVY, M. E. CSETE, K. A. TANAKA
  • Article Copyright Year:
  • 2009
  • Publication Volume:
  • 53
  • Publication Issue:
  • 3
  • Publication Date:
  • 03/01/2009
  • DOI:
  • https://doi.org/10.1111/j.1399-6576.2008.01858.x

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