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  • Pronounced transgenic tau expression and tangle formation in TAU58/2 mice. TAU58/2 mice express human tau (0N4R isoform) carrying the pathogenic P301S mutation. This results in pronounced expression of human tau throughout the brain of 3‐month‐old male and female TAU58/2 mice as demonstrated by (A) immunohistochemical staining and (B) Western blot analysis using the human tau‐specific antibody Tau13. (C) Representative Gallyas silver staining of male TAU58/2 mice at both 3 and 10 months (mo) of age demonstrates the presence of NFTs in various brain regions. (D) Quantification of Gallyas silver staining demonstrates significant increases in numbers of NFTs in the CTX, HIP and BS of male TAU58/2 mice over time, whereas female mice show significant increases in the CTX but not in the HIP (P = 0.071) or BS (P = 0.099). BS, brainstem; CTX, cerebral cortex; HIP, hippocampus; NFT, neurofibrillary tangle; non‐tg, non‐transgenic. n = 3/cohort. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Scale bars = 50 μm.
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  • John Wiley & Sons, Inc.
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  • Copyright © 2015 British Neuropathological Society
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  • Creator:
  • Janet Eersel, Claire H. Stevens, Magdalena Przybyla, Amadeus Gladbach, Kristie Stefanoska, Chesed Kai‐Xin Chan, Wei‐Yi Ong, John R. Hodges, Greg T. Sutherland, Jillian J. Kril, Dorothee Abramowski, Matthias Staufenbiel, Glenda M. Halliday, Lars M. Ittner
  • Credit:
  • Rademakers, R., Neumann, M., Mackenzie, I., Hodges, J., Davies, R., Xuereb, J., Kril, J., Halliday, G., Ratnavalli, E., Brayne, C., Dawson, K., Hodges, J., Hodges, J., Davies, R., Xuereb, J., Casey, B., Broe, M., Bak, T., Kril, J., Halliday, G., Burrell, J., Kiernan, M., Vucic, S., Hodges, J., Gotz, J., Ittner, L., Dickson, D., Feany, M., Yen, S., Mattiace, L., Davies, P., Murayama, S., Bouldin, T., Suzuki, K., Liao, L., Cheng, D., Wang, J., Duong, D., Losik, T., Gearing, M., Rees, H., Lah, J., Levey, A., Peng, J., Schmidt, M., Lee, V., Trojanowski, J., Galloway, P., Mulvihill, P., Perry, G., Josephs, K., Holton, J., Rossor, M., Braendgaard, H., Ozawa, T., Fox, N., Petersen, R., Pearl, G., Ganguly, M., Rosa, P., Laursen, H., Parisi, J., Waldemar, G., Quinn, N., Dickson, D., Revesz, T., Liu, Q., Xie, F., Alvarado‐Diaz, A., Smith, M., Moreira, P., Zhu, X., Perry, G., Cote, F., Collard, J., Julien, J., Stevens, M., Duijn, C., Kamphorst, W., Knijff, P., Heutink, P., Gool, W., Scheltens, P., Ravid, R., Oostra, B., Niermeijer, M., Swieten, J., Hutton, M., Lendon, C., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering‐Brown, S., Chakraverty, S., Isaacs, A., Grover, A., Hackett, J., Adamson, J., Lincoln, S., Dickson, D., Davies, P., Petersen, R., Stevens, M., Graaff, E., Wauters, E., Baren, J., Hillebrand, M., Joosse, M., Kwon, J., Nowotny, P., Che, L., Norton, J., Morris, J., Reed, L., Trojanowski, J., Basun, H., Lannfelt, L., Neystat, M., Fahn, S., Dark, F., Tannenberg, T., Dodd, P., Hayward, N., Kwok, J., Schofield, P., Andreadis, A., Snowden, J., Craufurd, D., Neary, D., Owen, F., Oostra, B., Hardy, J., Goate, A., Swieten, J., Mann, D., Lynch, T., Heutink, P., Abramowski, D., Rabe, S., Upadhaya, A., Reichwald, J., Danner, S., Staab, D., Capetillo‐Zarate, E., Yamaguchi, H., Saido, T., Wiederhold, K., Thal, D., Staufenbiel, M., Ittner, L., Ke, Y., Delerue, F., Bi, M., Gladbach, A., Eersel, J., Wolfing, H., Chieng, B., Christie, M., Napier, I., Eckert, A., Staufenbiel, M., Hardeman, E., Gotz, J., Ittner, L., Fath, T., Ke, Y., Bi, M., Eersel, J., Li, K., Gunning, P., Gotz, J., Gotz, J., Chen, F., Barmettler, R., Nitsch, R., Probst, A., Gotz, J., Wiederhold, K., Tolnay, M., Mistl, C., Jaton, A., Hong, M., Ishihara, T., Lee, V., Trojanowski, J., Jakes, R., Crowther, R., Spillantini, M., Burki, K., Goedert, M., Eersel, J., Bi, M., Ke, Y., Hodges, J., Xuereb, J., Gregory, G., Halliday, G., Gotz, J., Kril, J., Ittner, L., Eersel, J., Ke, Y., Liu, X., Delerue, F., Kril, J., Gotz, J., Ittner, L., Eersel, J., Ke, Y., Gladbach, A., Bi, M., Gotz, J., Kril, J., Ittner, L., Bugiani, O., Murrell, J., Giaccone, G., Hasegawa, M., Ghigo, G., Tabaton, M., Morbin, M., Primavera, A., Carella, F., Solaro, C., Grisoli, M., Savoiardo, M., Spillantini, M., Tagliavini, F., Goedert, M., Ghetti, B., Piguet, O., Brooks, W., Halliday, G., Schofield, P., Stanford, P., Kwok, J., Spillantini, M., Yancopoulou, D., Nestor, P., Broe, G., Hodges, J., Lomen‐Hoerth, C., Anderson, T., Miller, B., Lewis, J., & McGowan, E., Rockwood, J., Melrose, H., Nacharaju, P., Van Slegtenhorst, M., Gwinn‐Hardy, K., Paul Murphy, M., Baker, M., Yu, X., Duff, K., Hardy, J., Corral, A., Lin, W., Yen, S., Dickson, D., Davies, P., Hutton, M., Leroy, K., Bretteville, A., Schindowski, K., Gilissen, E., Authelet, M., De Decker, R., Yilmaz, Z., Buee, L., Brion, J., Spittaels, K., Van den Haute, C., Van Dorpe, J., Bruynseels, K., Vandezande, K., Laenen, I., Geerts, H., Mercken, M., Sciot, R., Van Lommel, A., Loos, R., Van Leuven, F., Pennanen, L., Welzl, H., D'Adamo, P., Nitsch, R., Gotz, J., Pennanen, L., Wolfer, D., Nitsch, R., Gotz, J., Kersaitis, C., Halliday, G., Kril, J., Brooks, S., Dunnett, S., Stanley, J., Lincoln, R., Brown, T., McDonald, L., Dawson, G., Reynolds, D., Uchihara, T., Augustinack, J., Schneider, A., Mandelkow, E.-M., Hyman, B., Gotz, J., Chen, F., Dorpe, J., Nitsch, R., Luna‐Munoz, J., Chavez‐Macias, L., Garcia‐Sierra, F., Mena, R., Gotz, J., Gladbach, A., Pennanen, L., Eersel, J., Schild, A., David, D., Ittner, L., Ishizawa, K., Dickson, D., Ittner, L., Gotz, J., Ittner, L., Ke, Y., Gotz, J., David, D., Hauptmann, S., Scherping, I., Schuessel, K., Keil, U., Rizzu, P., Ravid, R., Drose, S., Brandt, U., Muller, W., Eckert, A., Gotz, J., Rhein, V., Song, X., Wiesner, A., Ittner, L., Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Drose, S., Brandt, U., Savaskan, E., Czech, C., Gotz, J., Eckert, A., Ballatore, C., Lee, V., Trojanowski, J., Goedert, M., Spillantini, M., Ishihara, T., Hong, M., Zhang, B., Nakagawa, Y., Lee, M., Trojanowski, J., Lee, V., Probst, A., Tolnay, M., Langui, D., Goedert, M., Spillantini, M., Ahlijanian, M., Barrezueta, N., Williams, R., Jakowski, A., Kowsz, K., McCarthy, S., Coskran, T., Carlo, A., Seymour, P., Burkhardt, J., Nelson, R., McNeish, J., Ishihara, T., Higuchi, M., Zhang, B., Yoshiyama, Y., Hong, M., Trojanowski, J., Lee, V., Kong, J., Xu, Z., Williamson, T., Bruijn, L., Zhu, Q., Anderson, K., Anderson, S., Julien, J., Cleveland, D., Wang, L., Jiang, Q., Chu, J., Lin, L., Li, X., Chai, G., Wang, Q., Wang, J., Tian, Q., Petzold, A., Keir, G., Warren, J., Fox, N., Rossor, M., Gaiottino, J., Norgren, N., Dobson, R., Topping, J., Nissim, A., Malaspina, A., Bestwick, J., Monsch, A., Regeniter, A., Lindberg, R., Kappos, L., Leppert, D., Petzold, A., Giovannoni, G., Kuhle, J., Kuhle, J., Plattner, K., Bestwick, J., Lindberg, R., Ramagopalan, S., Norgren, N., Nissim, A., Malaspina, A., Leppert, D., Giovannoni, G., Kappos, L., Lapane, K., Gambassi, G., Landi, F., Sgadari, A., Mor, V., Bernabei, R., Carter, C., Resnick, E., Mallampalli, M., Kalbarczyk, A., Yue, M., Hanna, A., Wilson, J., Roder, H., Janus, C., Lewis, J., Dickson, D., Lin, W., Chisholm, L., Corral, A., Jones, G., Yen, S., Sahara, N., Skipper, L., Yager, D., Eckman, C., Hardy, J., Hutton, M., & McGowan, E. (2015). Early‐onset axonal pathology in a novel P301S‐Tau transgenic mouse model of frontotemporal lobar degeneration. Neuropathology and Applied Neurobiology, 41(7), 906-925..
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  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Janet Eersel, Claire H. Stevens, Magdalena Przybyla, Amadeus Gladbach, Kristie Stefanoska, Chesed Kai‐Xin Chan, Wei‐Yi Ong, John R. Hodges, Greg T. Sutherland, Jillian J. Kril, Dorothee Abramowski, Matthias Staufenbiel, Glenda M. Halliday, Lars M. Ittner
  • Article Copyright Year:
  • 2015
  • Publication Volume:
  • 41
  • Publication Issue:
  • 7
  • Publication Date:
  • 12/01/2015
  • DOI:

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