Asset Details

  • Description:
  • Kaplan Meier disease free survival curves according to serum mutant KRAS2, tumour mutant KRAS2, and disease stage. Survival analysis included only patients with Dukes' A, B, or C disease, as inclusion of patients with tubulovillous adenoma or Dukes' D may bias the results because of the low and high recurrence rates, respectively. Below, the symbols (+) and (−) refer to KRAS2 mutation status. (A) In n=85 patients, tumour (+) and (−), survival was significantly worse in serum (+) patients (p=0.0000). (B) In tumour (+) patients (n=54), survival was significantly worse in serum (+) patients (p=0.0000). (C) Stratification of n=54 patients who were tumour (+) on the basis of disease stage showed that serum (+) patients had a significantly worse prognosis in each disease stage (p=0.0000 for early disease and p=0.007 for late disease). The disease free survival curves were similar for patients who were serum (+) and who had either early or late disease and for patients who were serum (−) with either early or late disease.
  • License:
  • Rights Managed
  • Rights Holder:
  • BMJ
  • License Rights Holder:
  • Copyright 2003 by Gut
  • Asset Type:
  • Image
  • Asset Subtype:
  • Photo
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 1280 x 1141
  • Image File Size:
  • 195 KB
  • Creator:
  • B M Ryan, F Lefort, R McManus, J Daly, P W N Keeling, D G Weir, D Kelleher
  • Credit:
  • Ryan, B. M., et al., Gut, 52(1), 101.
  • Collection:
  • Keywords:
  • DNA, KRAS2 , KRAS2 mutation, prognosis, colorectal carcinoma, CRC, colorectal carcinoma, TVA, tubulovillous adenoma, CEA, carcinoembryonic antigen, OR, odds ratio, PCR, polymerase chain reaction
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • B M Ryan, F Lefort, R McManus, J Daly, P W N Keeling, D G Weir, D Kelleher
  • Article Copyright Year:
  • 2003
  • Publication Title:
  • Gut
  • Publication Volume:
  • 52
  • Publication Issue:
  • 1
  • Publication Date:
  • DOI:
  • https://doi.org/10.1136/gut.52.1.101

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