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  • Description:
  • Clinical, Histologic, and Clonal Response of Patients With Psoralen–UV-A (PUVA) TreatmentRepresentative cases of patients with complete response (CR) and partial response (PR). Baseline evaluation of clinical presentation, histologic features and high-throughput T-cell receptor sequencing results from skin biopsy specimens of patients 5 (A) and 22 (C) are shown. Respective reevaluation of these parameters after 16 (B) or 24 (D) weeks of PUVA induction treatment are depicted. The box in the clinical photographs indicates area of biopsy. Imaging of hematoxylin-eosin staining (original magnification ×20) was performed, and the infiltration density score (IDS) for each patient is shown. Plots of clonality analyses show the total count of T-cell receptor (TCR) reads per TCRBJ family. The malignant clone is annotated, and associated amino acid sequence and percentage of clonal TCR reads are shown.
  • License:
  • Rights Managed
  • Rights Holder:
  • JAMA
  • License Rights Holder:
  • Copyright 2019 American Medical Association. All Rights Reserved.
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 1960 x 2417
  • Image File Size:
  • 2.73 MB
  • Creator:
  • Pablo Vieyra-Garcia, Regina Fink-Puches, Stefanie Porkert, Roland Lang, Sophie Pöchlauer, Gudrun Ratzinger, Adrian Tanew, Sylvia Selhofer, Sator Paul-Gunther, Angelika Hofer, Alexandra Gruber-Wackernagel, Franz Legat, Vijaykumar Patra, Franz Quehenberger, Lorenzo Cerroni, Rachael Clark, Peter Wolf
  • Credit:
  • Vieyra-Garcia, P., Fink-Puches, R., Porkert, S., Lang, R., Pöchlauer, S., Ratzinger, G., Tanew, A., Selhofer, S., Paul-Gunther, S., Hofer, A., Gruber-Wackernagel, A., Legat, F., Patra, V., Quehenberger, F., Cerroni, L., Clark, R., & Wolf, P. (2019). Evaluation of Low-Dose, Low-Frequency Oral Psoralen–UV-A Treatment With or Without Maintenance on Early-Stage Mycosis Fungoides. JAMA Dermatology, 155(5), 538-548. https://doi.org/10.1001/jamadermatol.2018.5905.
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  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Pablo Vieyra-Garcia, Regina Fink-Puches, Stefanie Porkert, Roland Lang, Sophie Pöchlauer, Gudrun Ratzinger, Adrian Tanew, Sylvia Selhofer, Sator Paul-Gunther, Angelika Hofer, Alexandra Gruber-Wackernagel, Franz Legat, Vijaykumar Patra, Franz Quehenberger, Lorenzo Cerroni, Rachael Clark, Peter Wolf
  • Article Copyright Year:
  • Publication Volume:
  • 155
  • Publication Issue:
  • 5
  • Publication Date:
  • 05/08/2019
  • DOI:
  • https://doi.org/10.1001/jamadermatol.2018.5905

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