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  • Description:
  • Association Between β-Amyloid (Aβ) Amplitude and Linear Rise With Aβ42:Aβ40 RatioA, Aβ42 amplitude (picomolars [pM]) vs Aβ42:Aβ40 ratio (amyloid negative: r = 0.38; P = .02; amyloid positive: r = 0.11; P = .49). The horizontal dashed line is at 15 pM. B, Aβ42 linear rise (pM/h) vs Aβ42:Aβ40 ratio (amyloid negative: r = 0.26; P = .12; amyloid positive: r = 0.06; P = .70). C, Aβ40 amplitude (pM) vs Aβ42:Aβ40 ratio (amyloid negative: r = 0.16; P = .34; amyloid positive: r = 0.27; P = .10). The horizontal dashed line is at 200 pM. D, Aβ40 linear rise (pM/h) vs Aβ42:Aβ40 ratio (amyloid negative: r = 0.14; P = .41; amyloid positive: r = 0.1; P = .53). For all panels, the vertical dashes lines are at Aβ42:Aβ40 = 0.1, Aβ42:Aβ40 = 0.12, and Aβ42:Aβ40 = 0.16. Participants with the highest CSF Aβ42:Aβ40 ratios (>0.16) were previously reported to have normal Aβ stable isotope labeling kinetics (SILK). Aβ SILK alterations become progressively more pronounced as the CSF Aβ42:Aβ40 ratio decreases from 0.16 to 0.1 and then <0.1. For this reason, these cutoffs were used in the figures with Aβ42:Aβ40 ratio.
  • License:
  • Rights Managed
  • Rights Holder:
  • JAMA
  • License Rights Holder:
  • Copyright 2016 American Medical Association. All Rights Reserved.
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 1946 x 1384
  • Image File Size:
  • 129 KB
  • Creator:
  • Brendan P. Lucey, Kwasi G. Mawuenyega, Bruce W. Patterson, Donald L. Elbert, Vitaliy Ovod, Tom Kasten, John C. Morris, Randall J. Bateman
  • Credit:
  • Lucey, B. P., Mawuenyega, K. G., Patterson, B. W., Elbert, D. L., Ovod, V., Kasten, T., Morris, J. C., & Bateman, R. J. (2017). Associations Between β-Amyloid Kinetics and the β-Amyloid Diurnal Pattern in the Central Nervous System. JAMA Neurology, 74(2), 207-215. https://doi.org/10.1001/jamaneurol.2016.4202.
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  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Brendan P. Lucey, Kwasi G. Mawuenyega, Bruce W. Patterson, Donald L. Elbert, Vitaliy Ovod, Tom Kasten, John C. Morris, Randall J. Bateman
  • Article Copyright Year:
  • Publication Volume:
  • 74
  • Publication Issue:
  • 2
  • Publication Date:
  • 02/13/2017
  • DOI:
  • https://doi.org/10.1001/jamaneurol.2016.4202

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