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  • Description:
  • Expression of stearoyl–CoA desaturase‐1 (SCD1) in renal cancer cells and its response to hypoxia‐inducible factor‐2α (HIF‐2α) upregulation. (A) SCD1 levels in four representative specimen pairs (clear cell renal cell carcinoma [ccRCC] tumor [T] and their adjacent non‐tumorous parenchyma [N]) from ccRCC patients were analyzed with Western blot. CC#1–4 indicate specimen numbers. (B) Specimens from ccRCC patients were also subjected to immunohistological staining with an antibody against SCD1. (C) SCD1 expression was assayed in the HK‐2 cell line (taken as normal control [N]) and three ccRCC cell lines, A498, RCC4, and 786‐0, reported to have various HIFα isoform expressions. The HIF‐2α levels in ccRCC tumors were detected with immunohistochemistry. (D) Representative results from four specimen pairs. (E) SCD1 and HIF‐2α levels were analyzed in 786‐0 cells exposed to normoxia (21% O2) or hypoxia (0.5% O2).
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2013 Japanese Cancer Association
  • Asset Type:
  • Image
  • Asset Subtype:
  • Illustration
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • x
  • Image File Size:
  • 753 KB
  • Creator:
  • Yujian Zhang, Hui Wang, Jin Zhang, Jianwei Lv, Yiran Huang
  • Credit:
  • Zhang, Y., Wang, H., Zhang, J., Lv, J., & Huang, Y. (2013). Positive feedback loop and synergistic effects between hypoxia‐inducible factor‐2α and stearoyl–CoA desaturase‐1 promote tumorigenesis in clear cell renal cell carcinoma. Cancer Science, 104(4), 416-422..
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Yujian Zhang, Hui Wang, Jin Zhang, Jianwei Lv, Yiran Huang
  • Article Copyright Year:
  • 2013
  • Publication Volume:
  • 104
  • Publication Issue:
  • 4
  • Publication Date:
  • 04/01/2013
  • DOI:

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