Asset Details

  • Description:
  • Impact of stearoyl–CoA desaturase‐1 (SCD1) level change on PI3K/Akt pathway activation in 786‐0 renal cancer cells. Levels of SCD1 in 786‐0 cells were knocked down by transfecting siRNA against SCD1 (shSCD1) or increased by transiently transfecting an expression vector containing the full‐length SCD1 gene (SCD1). The scrambled sequence of shSCD1 (Ctrl) or empty vector (EV) was taken as control. Gene silencing effects of shSCD1 were determined by realtime RT‐PCR on SCD1 (A). Total Akt protein levels and Akt activation indicated by phosphorylation at Ser473 were evaluated under SCD1 deficiency (B) and overexpression (C).
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2013 Japanese Cancer Association
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • x
  • Image File Size:
  • 63.5 KB
  • Creator:
  • Yujian Zhang, Hui Wang, Jin Zhang, Jianwei Lv, Yiran Huang
  • Credit:
  • Zhang, Y., Wang, H., Zhang, J., Lv, J., & Huang, Y. (2013). Positive feedback loop and synergistic effects between hypoxia‐inducible factor‐2α and stearoyl–CoA desaturase‐1 promote tumorigenesis in clear cell renal cell carcinoma. Cancer Science, 104(4), 416-422..
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Yujian Zhang, Hui Wang, Jin Zhang, Jianwei Lv, Yiran Huang
  • Article Copyright Year:
  • 2013
  • Publication Volume:
  • 104
  • Publication Issue:
  • 4
  • Publication Date:
  • 04/01/2013
  • DOI:

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