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  • Description:
  • Histologic Features in Erythrodermic Psoriasis and Erythrodermic Atopic Dermatitis (AD)Biopsy specimens of erythrodermic psoriasis (A) and erythrodermic AD (B) show overlapping histologic features (A and B, hematoxylin-eosin, original magnification ×200). No significant difference is seen in the inflammatory phenotype present in erythrodermic psoriasis and erythrodermic AD as evaluated by the percentage of CD4+/T-bet+ cells (helper T-cell subtype 1 [TH1]; C and D, respectively), CD4+/GATA3+ cells (TH2 cells; E and F, respectively), CD4+/STAT3+ cells (TH17 cells; G and H, respectively), or CD4+/BNC2+ cells (TH22 cells; I and J, respectively). Positive staining is indicated by dual cytoplasmic (brown chromogen, eg, for CD4) and nuclear (blue chromogen, eg, for BNC2) positivity within a cell (C-J, original magnification ×400). BNC2 indicates basonuclin 2; GATA3, GATA binding protein 3; and STAT3, signal transducer and activator of transcription 3.
  • License:
  • Rights Managed
  • Rights Holder:
  • JAMA
  • License Rights Holder:
  • Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 1300 x 2501
  • Image File Size:
  • 4.99 MB
  • Creator:
  • Andrea Primiani Moy, Mandakolathur Murali, Daniela Kroshinsky, Lyn M. Duncan, Rosalynn M. Nazarian
  • Credit:
  • Moy, A. P., Murali, M., Kroshinsky, D., Duncan, L. M., & Nazarian, R. M. (2015). Immunologic Overlap of Helper T-Cell Subtypes 17 and 22 in Erythrodermic Psoriasis and Atopic Dermatitis. JAMA Dermatology, 151(7), 753-760. https://doi.org/10.1001/jamadermatol.2015.2.
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  • Keywords:
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  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Andrea Primiani Moy, Mandakolathur Murali, Daniela Kroshinsky, Lyn M. Duncan, Rosalynn M. Nazarian
  • Article Copyright Year:
  • Publication Volume:
  • 151
  • Publication Issue:
  • 7
  • Publication Date:
  • 07/08/2015
  • DOI:
  • https://doi.org/10.1001/jamadermatol.2015.2

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