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  • Description:
  • mASCsdb−/db− increase bone regeneration in diabetic bony defects. (A): Aniline blue staining of db−/db− control mice showed impaired new bone formation compared with WT control mice (left column), whereas diabetic defects treated with mASCsdb−/db− showed improved bone formation (right column) (7 dpo). Transplantation of mASCsdb−/db− and mASCsWT into WT mice did not improve bone formation. (B): Extracted osteoid formation area. (C): Quantification of aniline blue‐positive pixels revealed that bone formation is significantly increased in mASC‐treated diabetic defects compared with the control group db−/db− and similar to bone formation of WT mice. mASC implantation into WT mice did not show improved bone regeneration. Results are shown as means ± SEM. Scale bar = 200 μm. ∗, p < .05; ∗∗, p < .01; ∗∗∗, p < .001 (two‐sample t test). Abbreviations: Cb, cortical bone; Ctrl, control; d, days postoperation; mASC, mouse adipose‐derived stem cell; n.s., not significant; WT, wild type.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © AlphaMed Press
  • Asset Type:
  • Image
  • Asset Subtype:
  • Photo
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • x
  • Image File Size:
  • 319 KB
  • Creator:
  • Christoph Wallner, Stephanie Abraham, Johannes Maximilian Wagner, Kamran Harati, Britta Ismer, Lukas Kessler, Hannah Zöllner, Marcus Lehnhardt, Björn Behr
  • Credit:
  • Wallner, C., Abraham, S., Wagner, J. M., Harati, K., Ismer, B., Kessler, L., Zöllner, H., Lehnhardt, M., & Behr, B. (2016). Local Application of Isogenic Adipose‐Derived Stem Cells Restores Bone Healing Capacity in a Type 2 Diabetes Model. STEM CELLS Translational Medicine, 5(6), 836-844..
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  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Christoph Wallner, Stephanie Abraham, Johannes Maximilian Wagner, Kamran Harati, Britta Ismer, Lukas Kessler, Hannah Zöllner, Marcus Lehnhardt, Björn Behr
  • Article Copyright Year:
  • 2016
  • Publication Volume:
  • 5
  • Publication Issue:
  • 6
  • Publication Date:
  • 06/01/2016
  • DOI:

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