Asset Details

  • Description:
  • Modulation of in situ transforming growth factor (TGF)‐β2 protein expression by caffeine (C). (a,b) In male human hair follicles, testosterone (T) induced a significant upregulation of the catagen inductor TGF‐β2 to 122·7% vs. control (*P < 0·05). Caffeine 0·001% significantly reduced the TGF‐β2 expression to below normal (control) levels (97·6%; **P < 0·01). #1, #2 and #3 are exemplar images of the different treatment conditions from the hair follicle of one representative experiment; mean ± SEM; n = 9–11. (c,d) In female hair follicles, there was no relevant upregulation of TGF‐β2 by testosterone, but there was a significant decrease induced by caffeine 0·0005% from 102·5% to 89·2% (P < 0·01). #1 and #2 show images of the different treatment conditions from the hair follicles of two different individuals and are presented as mean ± SEM; n = 17–32. ORS, outer root sheath; He, Henle layer.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Copyright © 2014 British Association of Dermatologists
  • Asset Type:
  • Image
  • Asset Subtype:
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 1211 x 1333
  • Image File Size:
  • 578 KB
  • Creator:
  • T.W. Fischer, E. Herczeg‐Lisztes, W. Funk, D. Zillikens, T. Bíró, R. Paus
  • Credit:
  • Fischer, T. W., Herczeg‐Lisztes, E., Funk, W., Zillikens, D., Bíró, T., & Paus, R. (2014). Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles in vitro. British Journal of Dermatology, 171(5), 1031-1043..
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  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • T.W. Fischer, E. Herczeg‐Lisztes, W. Funk, D. Zillikens, T. Bíró, R. Paus
  • Article Copyright Year:
  • 2014
  • Publication Volume:
  • 171
  • Publication Issue:
  • 5
  • Publication Date:
  • 11/01/2014
  • DOI:

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