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  • Description:
  • Of 125 patients who underwent liver transplantations, 15 (12%) have SNHL. Of 5 survivors with the short-bowel syndrome, 4 have severe to profound SNHL (Figure 1). The remaining 4 patients who received liver transplants for the short-bowel syndrome are deceased, and audiometric evaluations are not available. The incidence of SNHL among the liver transplant recipients with the short-bowel syndrome is at least 44%. Among children with biliary atresia who underwent liver transplantation before 2 years of age, 8 (17%) of 46 have SNHL (Figure 2), and 26 of 46 were evaluable for this study. In these 26 children, a large cumulative dose of amikacin is a statistically significant risk factor for SNHL (P=.05). All 4 children who received the largest cumulative doses of amikacin, greater than 200 mg/kg, had SNHL (Figure 3). In contrast, only 2 of 22 children who received less than 90 mg/kg of amikacin had SNHL. The sample size limited the statistical power of this study, but there was a suggestive association with cumulative doses of intravenous furosemide (P=.10) that might be resolved by a larger study. Four of the 5 children who received the largest cumulative doses of intravenous furosemide had SNHL (Figure 4). Cumulative doses of gentamicin and tobramycin were not statistically significant risk factors for SNHL (Figure 5 and Figure 6).
  • License:
  • Rights Managed
  • Rights Holder:
  • JAMA
  • License Rights Holder:
  • Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 590 x 404
  • Image File Size:
  • 15.1 KB
  • Creator:
  • Ellen S. Deutsch MD, Victoria Bartling MA, Brian Lawenda MD, John Schwegler MA, Kathleen Falkenstein MSN, CRNP, Stephen Dunn MD
  • Credit:
  • Deutsch, E. S., Bartling, V., Lawenda, B., Schwegler, J., Falkenstein, K., & Dunn, S. (1998). Sensorineural Hearing Loss in Children After Liver Transplantation. Arch Otolaryngol Head Neck Surg, 124(5), 529-533. https://doi.org/10.1001/archotol.124.5.529.
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  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Ellen S. Deutsch MD, Victoria Bartling MA, Brian Lawenda MD, John Schwegler MA, Kathleen Falkenstein MSN, CRNP, Stephen Dunn MD
  • Article Copyright Year:
  • 1998
  • Publication Volume:
  • 124
  • Publication Issue:
  • 5
  • Publication Date:
  • 05/01/1998
  • DOI:
  • https://doi.org/10.1001/archotol.124.5.529

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