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  • Description:
  • Modulation of thiol redox status affects N‐methyl‐d‐aspartate receptor (NMDAR)‐dependent long‐term potentiation (LTP) in the hippocampus of adult rat. (A) Time‐course of LTP induced by theta‐burst stimulation (TBS) (arrow) in control (○, n = 11) and in slices treated with 50 μm APV (♦, n = 5 slices) from different adult rats. (B) Bar graph illustrating the mean increase (± SD) in field excitatory postsynaptic potentials (fEPSPs) slope averaged from 45 to 60 min after TBS in control and APV‐treated slices (*P < 0.05 vs. adult). (C) Effect of bath perfusion of 50 μm dithiothreitol (DTT) on basal fEPSPs recorded from the rat hippocampus in response to stimulation delivered every 30 s (n = 9 slices). (D) DTT enhanced NMDAR‐dependent LTP (n = 9 slices) in the hippocampus of adult rats (*P < 0.05 vs. adult). (E) Effect of bath perfusion of 100 μm DTNB on basal fEPSPs recorded from the rat hippocampus in response to stimulation delivered every 30 s (n = 8 slices). (F) DTNB inhibited NMDAR‐dependent LTP (n = 8 slices) in the hippocampus of adult rats (*P < 0.05 vs. adult). (G) Bar graph illustrating the mean increase in fEPSPs slope averaged from 45 to 60 min after TBS in control and each pharmacological conditions (*P < 0.05 vs. adult). Insets in A, D and F are superimposed examples of fEPSPs recorded for each condition before (1) and 60 min after the application of TBS (2). On the top in C and E, insets are sample traces taken at the times indicated on the graph. The time of acute application of drug is indicated by the black bar in the figures. All data are mean ± SD. (Correction added on 17 August 2010, after first online publication: In (C), DTT (100 μm) was corrected to DTT 50 μm.)
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2010 The Authors Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 850 x 1240
  • Image File Size:
  • 128 KB
  • Creator:
  • Yuan‐Jian Yang, Peng‐Fei Wu, Li‐Hong Long, Dan‐Fang Yu, Wen‐Ning Wu, Zhuang‐Li Hu, Hui Fu, Na Xie, You Jin, Lan Ni, Jian‐Zhi Wang, Fang Wang, Jian‐Guo Chen
  • Credit:
  • Yang, Y.-J., Wu, P.-F., Long, L.-H., Yu, D.-F., Wu, W.-N., Hu, Z.-L., Fu, H., Xie, N., Jin, Y., Ni, L., Wang, J.-Z., Wang, F., & Chen, J.-G. (2010). Reversal of aging‐associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function. Aging Cell, 9(5), 709-721. https://doi.org/10.1111/j.1474-9726.2010.00595.x.
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  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Yuan‐Jian Yang, Peng‐Fei Wu, Li‐Hong Long, Dan‐Fang Yu, Wen‐Ning Wu, Zhuang‐Li Hu, Hui Fu, Na Xie, You Jin, Lan Ni, Jian‐Zhi Wang, Fang Wang, Jian‐Guo Chen
  • Article Copyright Year:
  • 2010
  • Publication Volume:
  • 9
  • Publication Issue:
  • 5
  • Publication Date:
  • 10/01/2010
  • DOI:
  • https://doi.org/10.1111/j.1474-9726.2010.00595.x

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