Asset Details

  • Description:
  • Cytotoxicity of CAR NK cells against established and primary leukemia cells. Cell killing by CAR‐engineered NK‐92/4G8.28.z cells (filled triangles) was investigated in FACS‐based cytotoxicity assays after coincubation with established SEM, NALM‐16 and HL‐60 leukemia cells lines and KW primary B‐ALL blasts as targets at different effector to target ratios (E/T) for 4 hr. Parental NK‐92 (open circles) and NK‐92/4G8.TM cells expressing a truncated CAR (open triangles) were included for comparison. Similar experiments were performed to investigate activity of NK‐92/4G8.28.z and parental NK‐92 cells against sorted CD34+ hematopoietic stem cells from healthy donors (bottom panel). Mean values ± SEM are shown; n = 3. p Values for differences between treatments at the indicated E/T ratios were calculated by pairwise analysis using two‐tailed unpaired t‐test (shown for NK‐92/4G8.28.z vs. NK‐92/4G8.TM). ****, p < 0.0001; ***, p < 0.001; *, p < 0.05; ns: not significant (p > 0.05).
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2019 UICC
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 2128 x 3243
  • Image File Size:
  • 476 KB
  • Creator:
  • Sarah Oelsner, Anja Waldmann, Arne Billmeier, Jasmin Röder, Aline Lindner, Evelyn Ullrich, Rolf Marschalek, Gianpietro Dotti, Gundram Jung, Ludger Große‐Hovest, Pranav Oberoi, Peter Bader, Winfried S. Wels
  • Credit:
  • Oelsner, S., Waldmann, A., Billmeier, A., Röder, J., Lindner, A., Ullrich, E., Marschalek, R., Dotti, G., Jung, G., Große‐Hovest, L., Oberoi, P., Bader, P., & Wels, W. S. (2019). Genetically engineered CAR NK cells display selective cytotoxicity against FLT3‐positive B‐ALL and inhibit in vivo leukemia growth. International Journal of Cancer, 145(7), 1935-1945..
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Sarah Oelsner, Anja Waldmann, Arne Billmeier, Jasmin Röder, Aline Lindner, Evelyn Ullrich, Rolf Marschalek, Gianpietro Dotti, Gundram Jung, Ludger Große‐Hovest, Pranav Oberoi, Peter Bader, Winfried S. Wels
  • Article Copyright Year:
  • 2019
  • Publication Volume:
  • 145
  • Publication Issue:
  • 7
  • Publication Date:
  • 10/01/2019
  • DOI:

Click on image to enlarge

Would you like to download this asset? Tell us more and we can generate a quote, license and downloadable file.

Add to Cart