Asset Details
- Identifier:
- adb12483-fig-0001
- Description:
- N‐methyl‐d‐aspartate receptor subunit mRNA expression. Relative expression of NR1 and NR2 subunit mRNAs in (a) ventromedial prefrontal cortex, (b) amygdala and (c) nucleus accumbens (NAc), including diagrams representing where tissue was collected (adapted from Paxinos & Watson brain atlas). Wild‐type serotonin transporter rats are represented by white bars and serotonin transporter knockout rats by grey bars; all data represent mean (±SEM). Overall genotype * subunit interaction was found in the ventromedial prefrontal cortex [#F(4,109) = 30.695, P < 0.001] and NAc [$F(4,110) = 3.726, P < 0.01]. Post‐hoc independent sample t‐test analysis revealed that serotonin transporter knockout rats show a lower expression of NR1 [**t(21) = −3.017, P < 0.01] and higher expression of NR2A in the ventromedial prefrontal cortex [***t(22) = 8.620, P < 0.001] as well as a lower expression of NR2C in the NAc [***t(22) = −5.129, P < 0.001]
- License:
- Rights Managed
- Rights Holder:
- John Wiley & Sons, Inc.
- License Rights Holder:
- © 2018 Society for the Study of Addiction
- Asset Type:
- Image
- Asset Subtype:
- Illustration
- Image Orientation:
- Portrait
- Image Dimensions:
- 2128 x 2703
- Image File Size:
- 1.08 MB
- Creator:
- Peter Karel, Francesca Calabrese, Marco Riva, Paola Brivio, Bas Van der Veen, Liesbeth Reneman, Michel Verheij, Judith Homberg
- Credit:
- Karel, P., Calabrese, F., Riva, M., Brivio, P., Van der Veen, B., Reneman, L., Verheij, M., Homberg, J., Ahmed, S., Koob, G., Botreau, F., Paolone, G., Stewart, J., Burgos‐Robles, A., Vidal‐Gonzalez, I., Santini, E., Quirk, G., Calabrese, F., Guidotti, G., Molteni, R., Racagni, G., Mancini, M., Riva, M., Cao, J., Hudziak, J., Li, D., De Kleine, R., Hendriks, G., Smits, J., Broekman, T., Minnen, A., De Vries, T., Schoffelmeer, A., Binnekade, R., Mulder, A., Vanderschuren, L., Dravid, S., Burger, P., Prakash, A., Geballe, M., Yadav, R., Le, P., Vellano, K., Snyder, J., Traynelis, S., El Rawas, R., Klement, S., Salti, A., Fritz, M., Dechant, G., Saria, A., Zernig, G., Feinn, R., Nellissery, M., Kranzler, H., Gokturk, C., Schultze, S., Nilsson, K., Knorring, L., Oreland, L., Hallman, J., Hariri, A., Mattay, V., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M., Weinberger, D., Heils, A., Teufel, A., Petri, S., Stober, G., Riederer, P., Bengel, D., Lesch, K., Ho, Y., Hsu, L., Wang, C., Hsu, W., Lai, T., Hsu, C., Tsai, Y., & Holmes, A., Murphy, D., Crawley, J., Homberg, J., De Boer, S., Raaso, H., Olivier, J., Verheul, M., Ronken, E., Cools, A., Ellenbroek, B., Schoffelmeer, A., Vanderschuren, L., De Vries, T., Cuppen, E., Homberg, J., Olivier, J., Smits, B., Mul, J., Mudde, J., Verheul, M., Nieuwenhuizen, O., Cools, A., Ronken, E., Cremers, T., Schoffelmeer, A., Ellenbroek, B., Cuppen, E., Hood, W., Compton, R., Monahan, J., Hope, B., Nye, H., Kelz, M., Self, D., Iadarola, M., Nakabeppu, Y., Duman, R., Nestler, E., Huston, J., Silva, M., Topic, B., Muller, C., Jansen, F., Heiming, R., Lewejohann, L., Touma, C., Palme, R., Schmitt, A., Lesch, K., Sachser, N., Kelz, M., Chen, J., Carlezon, W., Whisler, K., Gilden, L., Beckmann, A., Steffen, C., Zhang, Y., Marotti, L., Self, D., Tkatch, T., Baranauskas, G., Surmeier, D., Neve, R., Duman, R., Picciotto, M., Nestler, E., Kennedy, A., Gross, R., Whitfield, N., Drexler, K., Kilts, C., LaLumiere, R., Niehoff, K., Kalivas, P., Ledgerwood, L., Richardson, R., Cranney, J., MacKillop, J., Few, L., Stojek, M., Murphy, C., Malutinok, S., Johnson, F., Hofmann, S., McGeary, J., Swift, R., Monti, P., Molteni, R., Calabrese, F., Maj, P., Olivier, J., Racagni, G., Ellenbroek, B., Riva, M., Munafo, M., Brown, S., Hariri, A., Nader, J., Chauvet, C., Rawas, R., Favot, L., Jaber, M., Thiriet, N., Solinas, M., Nestler, E., Nestler, E., Barrot, M., Self, D., Nonkes, L., Pooter, M., Homberg, J., Olivier, J., Van Der Hart, M., Van Swelm, R., Dederen, P., Homberg, J., Cremers, T., Deen, P., Cuppen, E., Cools, A., Ellenbroek, B., Pang, R., Wang, Z., Klosinski, L., Guo, Y., Herman, D., Celikel, T., Dong, H., Holschneider, D., Paxinos, G., Watson, C., Perrotti, L., Weaver, R., Robison, B., Renthal, W., Maze, I., Yazdani, S., Elmore, R., Knapp, D., Selley, D., Martin, B., Sim‐Selley, L., Bachtell, R., Self, D., Nestler, E., Peters, J., Kalivas, P., Quirk, G., Pezawas, L., Meyer‐Lindenberg, A., Drabant, E., Verchinski, B., Munoz, K., Kolachana, B., Egan, M., Mattay, V., Hariri, A., Weinberger, D., Popik, P., Wrobel, M., Bisaga, A., Price, K., Baker, N., McRae‐Clark, A., Saladin, M., Desantis, S., Santa Ana, E., Brady, K., Prisciandaro, J., Myrick, H., Henderson, S., McRae‐Clark, A., Santa Ana, E., Saladin, M., Brady, K., Santa Ana, E., Prisciandaro, J., Saladin, M., McRae‐Clark, A., Shaftman, S., Nietert, P., Brady, K., Santa Ana, E., Rounsaville, B., Frankforter, T., Nich, C., Babuscio, T., Poling, J., Gonsai, K., Hill, K., Carroll, K., Schipper, P., Kiliaan, A., Homberg, J., Sheinin, A., Shavit, S., Benveniste, M., Smits, B., Mudde, J., Plasterk, R., Cuppen, E., Smits, B., Mudde, J., Belt, J., Verheul, M., Olivier, J., Homberg, J., Guryev, V., Cools, A., Ellenbroek, B., Plasterk, R., Cuppen, E., Thanos, P., Bermeo, C., Wang, G., Volkow, N., Verheij, M., Contet, C., Karel, P., Latour, J., Van der Doelen, R., Kozicz, T., Homberg, J., Koob, G., Verheij, M., Contet, C., Nonkes, L., Latour, J., Hanisch, J., Vendruscolo, L., Edwards, S., Koob, G., Homberg, J., Vialou, V., Bagot, R., Cahill, M., Ferguson, D., Robison, A., Dietz, D., Fallon, B., Mazei‐Robison, M., Ku, S., Harrigan, E., Winstanley, C., Joshi, T., Feng, J., Berton, O., Nestler, E., Walker, D., Ressler, K., Lu, K., Davis, M., Wellman, C., Izquierdo, A., Garrett, J., Martin, K., Carroll, J., Millstein, R., Lesch, K., Murphy, D., & Holmes, A. (2018). d‐Cycloserine enhanced extinction of cocaine‐induced conditioned place preference is attenuated in serotonin transporter knockout rats. Addiction Biology, 23(1), 120-129. https://doi.org/10.1111/adb.12483.
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- Keywords:
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- Property Release:
- No
- Model Release:
- No
- Purchasable:
- Yes
- Sensitive Materials:
- No
- Article Title:
- d‐Cycloserine enhanced extinction of cocaine‐induced conditioned place preference is attenuated in serotonin transporter knockout rats
- Article Authors:
- Peter Karel, Francesca Calabrese, Marco Riva, Paola Brivio, Bas Van der Veen, Liesbeth Reneman, Michel Verheij, Judith Homberg
- Article Copyright Year:
- 2018
- Publication Title:
- Addiction Biology
- Publication Volume:
- 23
- Publication Issue:
- 1
- Publication Date:
- 01/01/2018
- DOI:
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