Asset Details

  • Description:
  • Identification of the TAI cell subset in humans. (a) Heatmap of CD8+ T-cell phenotypes (pre-gated on CD45+ CD3+ CD4− cells) in tumors of 5 human colorectal cancer (MMRd) patients. Dendrogram above shows the hierarchical similarity between the identified clusters. Right panel shows the frequency of CD8+ LAG3+ ICOS+ cells (cluster 8) among total CD8+ T cells across the 5 patients. (b) Gating strategy to identify the CD4+ CD69+ PD1+ CD39+ ICOS+ population in human colorectal cancer. The abundance proportional to circle area is shown
  • License:
  • Rights Managed
  • Rights Holder:
  • Springer Nature
  • License Rights Holder:
  • © The Author(s). 2019
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 1943 x 1788
  • Image File Size:
  • 444 KB
  • Creator:
  • Guillaume Beyrend, Esmé van der Gracht, Ayse Yilmaz, Suzanne van Duikeren, Marcel Camps, Thomas Höllt, Anna Vilanova, Vincent van Unen, Frits Koning, Noel F. C. C. de Miranda, Ramon Arens, Ferry Ossendorp
  • Credit:
  • Beyrend, G., van der Gracht, E., Yilmaz, A., van Duikeren, S., Camps, M., Höllt, T., Vilanova, A., van Unen, V., Koning, F., de Miranda, N. F. C. C., Arens, R., & Ossendorp, F. (2019). PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors. Journal for ImmunoTherapy of Cancer, 7(1), 217. https://doi.org/10.1186/s40425-019-0700-3.
  • Collection:
  • Keywords:
  • Mass cytometry, Combinatorial immunotherapy, T cells
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Guillaume Beyrend, Esmé van der Gracht, Ayse Yilmaz, Suzanne van Duikeren, Marcel Camps, Thomas Höllt, Anna Vilanova, Vincent van Unen, Frits Koning, Noel F. C. C. de Miranda, Ramon Arens, Ferry Ossendorp
  • Article Copyright Year:
  • 2019
  • Publication Volume:
  • 7
  • Publication Issue:
  • 1
  • Publication Date:
  • 08/14/2019
  • DOI:
  • https://doi.org/10.1186/s40425-019-0700-3

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