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  • Description:
  • Early protective effect of stromal vascular fraction (SVF) preischemic administration on acute renal IR injury. (A, B): Rats that received SVF administration showed significantly lower BUN (A) and SCr (B) values at 12, 24, and 72 hours after IR compared with control group. (C–E): SVF administration could also significantly reduce tubular injury score of kidneys in rats at 12 (C), 24 (D), and 72 (E) hours after IR compared with the control group. Although there was no significant difference in renal function and histopathological score between preischemic and postischemic groups, preischemic administration of SVF still contributed to lower BUN and SCr values, as well as reduced tubular injury, compared with postischemic administration. (F, G): Representative images of H&E staining preformed on sections of kidneys at 12, 24, and 72 hours after IR in different groups (magnification, ×400). Scale bars = 50 μm. ∗, p < .05 (vs. sham, IR+SVF pre‐I, and IR+SVF post‐I). Abbreviations: BUN, blood urea nitrogen; IR, ischemia/reperfusion; PBS, phosphate‐buffered saline; SCr, serum creatinine; SVF Post‐I, postischemic administration of stromal vascular fraction; SVF Pre‐I, preischemic administration of stromal vascular fraction.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © AlphaMed Press
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 854 x 768
  • Image File Size:
  • 1.06 MB
  • Creator:
  • Liuhua Zhou, Luwei Xu, Jiangwei Shen, Qun Song, Ran Wu, Yuzheng Ge, Hui Xin, Jiageng Zhu, Jianping Wu, Ruipeng Jia
  • Credit:
  • Zhou, L., Xu, L., Shen, J., Song, Q., Wu, R., Ge, Y., Xin, H., Zhu, J., Wu, J., & Jia, R. (2016). Preischemic Administration of Nonexpanded Adipose Stromal Vascular Fraction Attenuates Acute Renal Ischemia/Reperfusion Injury and Fibrosis. STEM CELLS Translational Medicine, 5(9), 1277-1288..
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Liuhua Zhou, Luwei Xu, Jiangwei Shen, Qun Song, Ran Wu, Yuzheng Ge, Hui Xin, Jiageng Zhu, Jianping Wu, Ruipeng Jia
  • Article Copyright Year:
  • 2016
  • Publication Volume:
  • 5
  • Publication Issue:
  • 9
  • Publication Date:
  • 09/01/2016
  • DOI:

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