Asset Details

  • Description:
  • Hematopoietic aging. (A): Measured cell frequencies in long‐term hematopoietic stem cell (HSC), short‐term HSC, and LMPP compartments for young (10–12 weeks), middle‐aged (40–54 weeks), and old (more than 86 weeks) mice. Vertical lines represent the standard error of the mean of the measurements (see Supporting Information for further details on cell sorting). (B): Measured compartment size ratios. (C): Cell frequencies predicted by the model (left‐hand side) for a given changing s(t) of the frequency of symmetric repopulating HSC divisions with age (right‐hand side, see Supporting Information for further mathematical details). Cell frequencies are calculated by dividing the model solution by the median total BM cell number which was used for cell sorting.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2019 AlphaMed Press
  • Asset Type:
  • Image
  • Asset Subtype:
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 2128 x 3644
  • Image File Size:
  • 591 KB
  • Creator:
  • Markus Klose, Maria Carolina Florian, Alexander Gerbaulet, Hartmut Geiger, Ingmar Glauche
  • Credit:
  • Klose, M., Florian, M. C., Gerbaulet, A., Geiger, H., & Glauche, I. (2019). Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach. STEM CELLS, 37(7), 948-957..
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Markus Klose, Maria Carolina Florian, Alexander Gerbaulet, Hartmut Geiger, Ingmar Glauche
  • Article Copyright Year:
  • 2019
  • Publication Volume:
  • 37
  • Publication Issue:
  • 7
  • Publication Date:
  • 07/01/2019
  • DOI:

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