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  • Description:
  • Endogenous Wnt signaling promotes Hcn4‐positive and Tbx3‐positive cardiomyocytes from mouse embryonic stem cells. A, Representative confocal images of 3‐week‐old differentiated cells of the CDM group (top row) and WM group (bottom row) stained with antibodies against α‐sarcomeric actinin (α‐SA, red) and Hcn4 (green). Nuclei were stained with DAPI (blue). B, Confocal images of the CDM group (top row) and WM group (bottom row) cells stained with antibodies against α‐SA (red) and Tbx3 (green). C, Western blotting analyses of Hcn4, cTnT, and β‐actin of CDM (black bar) and WM (red bar) groups. *P < .01 versus corresponding values in CDM, n = 4 biological replicates per group. CDM, cardiac differentiation medium; WM, Wnt‐uninhibited medium
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2020 AlphaMed Press
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 2128 x 2719
  • Image File Size:
  • 4.5 MB
  • Creator:
  • Wenbin Liang, Pengcheng Han, Elizabeth H. Kim, Jordan Mak, Rui Zhang, Angelo G. Torrente, Joshua I. Goldhaber, Eduardo Marbán, Hee Cheol Cho
  • Credit:
  • Liang, W., Han, P., & Kim, E. (2020). Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells. STEM CELLS, 38(3), 352-368. https://doi.org/10.1002/stem.3106.
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Wenbin Liang, Pengcheng Han, Elizabeth H. Kim, Jordan Mak, Rui Zhang, Angelo G. Torrente, Joshua I. Goldhaber, Eduardo Marbán, Hee Cheol Cho
  • Article Copyright Year:
  • 2020
  • Publication Volume:
  • 38
  • Publication Issue:
  • 3
  • Publication Date:
  • 03/01/2020
  • DOI:
  • https://doi.org/10.1002/stem.3106

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