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  • Description:
  • Polaris and AC6 depletion inhibits flow‐induced decreases in cAMP via a mechanism that involves Gd3+‐sensitive ion channels but not release of Ca2+ from intracellular stores. A) Flow/no flow intracellular cAMP levels immediately following 2 min of flow exposure in cells treated with control, polaris, and AC6 siRNA. Flow‐induced decreases in intracellular cAMP levels were significantly inhibited in polaris‐ and AC6‐depleted cells. B) Flow/no flow intracellular cAMP levels following 2 min of flow in untreated cells and cells treated with thapsigargin or Gd3+. Intracellular cAMP levels significantly decreased in response to flow in untreated cells and cells treated with thapsigargin; however this response was lost in cells treated with Gd3+.*P < 0.05, **P < 0.01, ***P < 0.001.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © Federation of American Societies for Experimental Biology
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 1800 x 859
  • Image File Size:
  • 213 KB
  • Creator:
  • Ronald Y. Kwon, Sara Temiyasathit, Padmaja Tummala, Clarence C. Quah, Christopher R. Jacobs
  • Credit:
  • Kwon, R. Y., Temiyasathit, S., Tummala, P., Quah, C. C., & Jacobs, C. R. (2010). Primary cilium‐dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells. The FASEB Journal, 24(8), 2859-2868. www.fasebj.org.
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  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Ronald Y. Kwon, Sara Temiyasathit, Padmaja Tummala, Clarence C. Quah, Christopher R. Jacobs
  • Article Copyright Year:
  • 2010
  • Publication Volume:
  • 24
  • Publication Issue:
  • 8
  • Publication Date:
  • 08/01/2010
  • DOI:
  • www.fasebj.org

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