Asset Details

  • Description:
  • Only TLCA mildly modulated rP2X1 and rP2X4 currents. a Representative current traces of P2X1, P2X3, and P2X4 expressed in Xenopus laevis oocytes repetitively activated by ATP (P2X1, P2X3 0.3 μM; P2X4 3 μM). THDCA (20 μM) or TLCA (200 μM) (black bars) were pre- and co-applied as indicated by the blue bars. b Mean current amplitudes in the presence of the indicated bile acid relative to the average of the previous and the subsequent ATP-activated currents, n = 8–13. c Representative current trace of P2X7 expressed in Xenopus laevis oocytes activated by ATP (1.7 mM). Pre- and co-application of THDCA (20 μM) or TLCA (200 μM) (blue bars) or control (gray bar) did not affect current amplitude. d Mean current amplitudes in the presence of the indicated bile acid relative to the average of the current amplitude before and after bile acid coapplication. n = 6–9; error bars represent S.E.M.
  • License:
  • Rights Managed
  • Rights Holder:
  • Springer Nature
  • License Rights Holder:
  • © Springer Nature B.V. 2019
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 1295 x 1655
  • Image File Size:
  • 119 KB
  • Creator:
  • Axel Schmidt, Sylvia Joussen, Ralf Hausmann, Stefan Gründer, Dominik Wiemuth
  • Credit:
  • Schmidt, A., Joussen, S., Hausmann, R., Gründer, S., & Wiemuth, D. (2019). Bile acids are potent inhibitors of rat P2X2 receptors. Purinergic Signalling, 15(2), 213-221. https://doi.org/10.1007/s11302-019-09657-2.
  • Collection:
  • Keywords:
  • P2X , Bile acid , Cation channel
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Axel Schmidt, Sylvia Joussen, Ralf Hausmann, Stefan Gründer, Dominik Wiemuth
  • Article Copyright Year:
  • 2019
  • Publication Volume:
  • 15
  • Publication Issue:
  • 2
  • Publication Date:
  • 05/17/2019
  • DOI:
  • https://doi.org/10.1007/s11302-019-09657-2

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