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  • Description:
  • ERK1/2 inhibition reduces angiotensin (ANG) II‐induced vasoconstriction and altered responses to NECA in MAs from WT mice. (A) PD98059 (1 μM), an ERK1/2 inhibitor, significantly reduced ANG II (10 nM)‐induced vasoconstrictions (control n = 10, PD98059 n= 6; *P < 0.05 compared with control). (B) Altered response to NECA after ANG II stimulation was also blocked by PD98059. *P < 0.05 compared with control NECA response, and #P < 0.05 compared with response after PD98059 treatment.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Copyright © 2015 The British Pharmacological Society
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • 628 x 723
  • Image File Size:
  • 36.6 KB
  • Creator:
  • Vishal R Yadav, Mohammed A Nayeem, Stephen L Tilley, S Jamal Mustafa
  • Credit:
  • Yadav, V. R., Nayeem, M. A., Tilley, S. L., Mustafa, S. J., Abdellatif, M., Neubauer, C., Lederer, W., Rogers, T., Alexander, S., Benson, H., Faccenda, E., Pawson, A., Sharman, J., Spedding, M., Alexander, S., Benson, H., Faccenda, E., Pawson, A., Sharman, J., Catterall, W., Alexander, S., Benson, H., Faccenda, E., Pawson, A., Sharman, J., Spedding, M., Ansari, H., Nadeem, A., Tilley, S., & Mustafa, S., Ansari, H., Teng, B., Nadeem, A., Roush, K., Martin, K., Schnermann, J., Berwick, Z., Payne, G., Lynch, B., Dick, G., Sturek, M., Tune, J., El‐Awady, M., Rajamani, U., Teng, B., Tilley, S., & Mustafa, S., Fahim, M., Hussain, T., & Mustafa, S., Fahim, M., & Mustafa, S., Fujii, K., Onaka, U., Goto, K., Abe, I., Fujishima, M., Gao, X., Patzak, A., Sendeski, M., Scheffer, P., Teerlink, T., Sallstrom, J., Haller, H., Lindschau, C., Erdmann, B., Quass, P., Luft, F., Harder, D., Gebremedhin, D., Narayanan, J., Jefcoat, C., Falck, J., Campbell, W., Hayabuchi, Y., Davies, N., Standen, N., Hein, T., Xu, W., Ren, Y., Kuo, L., Jacobson, K., Gao, Z., Kost, C., Herzer, W., Rominski, B., Mi, Z., Jackson, E., Kunduri, S., Dick, G., Nayeem, M., Mustafa, S., Kunduri, S., & Mustafa, S., Ponnoth, D., Dick, G., Nayeem, M., Lai, E., Patzak, A., Steege, A., Mrowka, R., Brown, R., Spielmann, N., Lee, D., Bell, T., Bhupatkar, J., Solis, G., Welch, W., Li, J., Fenton, R., Wheeler, H., Powell, C., Peyton, B., Cutler, B., McGiff, J., Laniado‐Schwartzman, M., McGiff, J., Steinberg, M., Quilley, J., Mubagwa, K., Flameng, W., Mubagwa, K., Mullane, K., Flameng, W., Muthalif, M., Benter, I., Karzoun, N., Fatima, S., Harper, J., Uddin, M., Muthalif, M., Karzoun, N., Gaber, L., Khandekar, Z., Benter, I., Saeed, A., Nayeem, M., Poloyac, S., Falck, J., Zeldin, D., Ledent, C., Ponnoth, D., Ohisalo, J., Olanrewaju, H., & Mustafa, S., Olanrewaju, H., Qin, W., Feoktistov, I., Scemama, J., & Mustafa, S., Paul, M., Poyan, M., Kreutz, R., Pawson, A., Sharman, J., Benson, H., Faccenda, E., Alexander, S., Buneman, O., Ponnoth, D., Nayeem, M., Kunduri, S., Tilley, S., Zeldin, D., Ledent, C., Ponnoth, D., Nayeem, M., Tilley, S., Ledent, C., Jamal Mustafa, S., Pradhan, I., Zeldin, D., Ledent, C., Mustafa, J., Falck, J., Nayeem, M., Rogel, A., Bromberg, Y., Sperling, O., Zoref‐Shani, E., Sampson, L., Davies, L., Barrett‐Jolley, R., Standen, N., Dart, C., Sanjani, M., Teng, B., Krahn, T., Tilley, S., Ledent, C., & Mustafa, S., Sasamura, H., Dzau, V., Pratt, R., Sharifi‐Sanjani, M., Zhou, X., Asano, S., Tilley, S., Ledent, C., Teng, B., Tawfik, H., Schnermann, J., Oldenburg, P., & Mustafa, S., Teng, B., Fil, D., Tilley, S., Ledent, C., Krahn, T., & Mustafa, S., Uehara, Y., Numabe, A., Hirawa, N., Kawabata, Y., Nagoshi, H., Kaneko, H., Zaman, M., Oparil, S., Calhoun, D., Zhang, W., Zhang, Y., Wang, W., Dai, Y., Ning, C., Luo, R., Zhou, X., Teng, B., Tilley, S., & Mustafa, S. (2015). Angiotensin II stimulation alters vasomotor response to adenosine in mouse mesenteric artery: role for A1 and A2B adenosine receptors. British Journal of Pharmacology, 172(20), 4959-4969. https://doi.org/10.1111/bph.13265.
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Vishal R Yadav, Mohammed A Nayeem, Stephen L Tilley, S Jamal Mustafa
  • Article Copyright Year:
  • 2015
  • Publication Volume:
  • 172
  • Publication Issue:
  • 20
  • Publication Date:
  • 10/01/2015
  • DOI:

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