Asset Details

  • Description:
  • Effects of E‐7229 and GLG‐V‐13 on corrected QT interval according to Bazett's formula (QTcb) in conscious rabbits. Protocol I for E‐7229 (A), Protocol I for GLG‐V‐13 (B); the data above the dose of 8.5 μmol/kg could not be collected due to presence of fatal cardiac arrhythmias (TdP/VF) in response to escalating compound doses. Protocol II for E‐7229 (C), Protocol III for E‐7229 (D); the data above the dose of 15.0 μmol/kg could not be collected due to presence of fatal cardiac arrhythmias (TdP/VF) in response to escalating compound doses. For details on infusion protocols (Protocols I, II, III), see text. Full squares denote the values measured in rabbits treated with E‐7229. Open squares represent the values obtained from animals treated with solvent for E‐7229. Full circles denote the values measured in rabbits treated with GLG‐V‐13. Open circles represent the values obtained from animals treated with solvent for GLG‐V‐13. The data are means ± SD obtained with 10 animals. (*P < 0.05, E‐7229/GLG‐V‐13 vs solvent; #P < 0.05, E‐7229 vs GLG‐V‐13).
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 1358 x 1116
  • Image File Size:
  • 321 KB
  • Creator:
  • László Drimba, Jozsef Nemeth, Réka Sári, Yin Di, Anikó Kovács, Gábor Szénási, Zoltán Szilvássy, Barna Peitl
  • Credit:
  • Drimba, L., Nemeth, J., Sári, R., Di, Y., Kovács, A., Szénási, G., Szilvássy, Z., & Peitl, B. (2013). In Vivo Preclinical Evaluation of a Promising Antiarrhythmic Agent, EGIS‐7229. Drug Development Research, 74(3), 173-185..
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • László Drimba, Jozsef Nemeth, Réka Sári, Yin Di, Anikó Kovács, Gábor Szénási, Zoltán Szilvássy, Barna Peitl
  • Article Copyright Year:
  • 2013
  • Publication Volume:
  • 74
  • Publication Issue:
  • 3
  • Publication Date:
  • 05/01/2013
  • DOI:

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