Asset Details

  • Description:
  • Novel CAR designs to reduce off‐tumor effects. Synergistic; two distinct CARs with different antigens. Stimulation of one CAR results in suboptimal activity thus the presence of two tumor antigens is required for a full anti‐tumor effect. iCARs; inhibitory CARs targeted towards a non‐tumor antigen results in downstream inhibition of the tumor‐targeted CAR, therefore normal tissue expressing basal levels of tumor antigen are protected. Co‐stimulatory CARs; two separate CARs targeting different tumor antigens, CAR 1 has an intracellular signaling domain for activation, whereas CAR 2 contains co‐stimulatory domains. Only in the presence of two tumor antigens will both activation and co‐stimulation occur, resulting in full effector functions. SynNotch CARs; CAR recognition of the tumor antigen results in downstream cleavage of the intracellular transcriptional domain. This allows for transcription of the target genes (such as chemokines/inhibitors) only after tumor antigen recognition. AND‐gate CARs; using the SynNotch CAR technology, the extracellular CAR is specific for tumor‐localized antigen (based on the tumor location and thus normal antigen profile), which on antigen recognition results in the transcription and expression of a CAR directed against the tumor antigen. A full color version of this figure is available online at the Immunology and Cell Biology website.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © Australasian Society for Immunology Inc.
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 1800 x 1346
  • Image File Size:
  • 444 KB
  • Creator:
  • Carmen S M Yong, Valerie Dardalhon, Christel Devaud, Naomi Taylor, Phillip K Darcy, Michael H Kershaw
  • Credit:
  • Yong, C. S. M., Dardalhon, V., Devaud, C., Taylor, N., Darcy, P. K., & Kershaw, M. H. (2017). CAR T‐cell therapy of solid tumors. Immunology and Cell Biology, 95(4), 356-363. https://doi.org/10.1038/icb.2016.128.
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Carmen S M Yong, Valerie Dardalhon, Christel Devaud, Naomi Taylor, Phillip K Darcy, Michael H Kershaw
  • Article Copyright Year:
  • 2017
  • Publication Volume:
  • 95
  • Publication Issue:
  • 4
  • Publication Date:
  • 04/01/2017
  • DOI:
  • https://doi.org/10.1038/icb.2016.128

Click on image to enlarge

Would you like to download this asset? Tell us more and we can generate a quote, license and downloadable file.

Add to Cart