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  • Description:
  • Schematic illustration of the role of the renal medullary endothelin (ET) system in sodium and water handling. Arginine‐vasopressin (AVP), angiotensin II (Ang II) and high dietary salt intake increase medullary interstitial tonicity, which stimulates ET‐1 expression. The major site for ET‐1 production is the inner medullary collecting duct, and in lesser quantities the medullary thick ascending limb (not shown). ET‐1 is released basolaterally and binds in an autocrine or paracrine fashion to ETB receptors, which inhibit apical sodium and water absorption, thereby inducing natriuresis and diuresis. ET‐1 additionally stimulates the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in tubular epithelial cells by ETB receptors and in medullary interstitial cells presumably by both ETA and ETB receptors. NO and PGE2 increase medullary perfusion by dilatory effects on pericytes of descending vasa recta (DVR), which entails solute washout and a decline in interstitial tonicity, which contributes to the diuretic effects of ET‐1. In addition, NO and PGE2 directly inhibit solute and water reabsorption. For details see text.
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2009 The Authors. Journal Compilation © 2009 Blackwell Publishing Ltd
  • Asset Type:
  • Image
  • Asset Subtype:
  • Figure
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • x
  • Image File Size:
  • 37.8 KB
  • Creator:
  • W. Neuhofer, D. Pittrow
  • Credit:
  • Neuhofer, W., & Pittrow, D. (2009). Endothelin receptor selectivity in chronic kidney disease: rationale and review of recent evidence. European Journal of Clinical Investigation, 39 50-67. https://doi.org/10.1111/j.1365-2362.2009.02121.x.
  • Collection:
  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • W. Neuhofer, D. Pittrow
  • Article Copyright Year:
  • 2009
  • Publication Volume:
  • 39
  • Publication Issue:
  • Publication Date:
  • 06/01/2009
  • DOI:
  • https://doi.org/10.1111/j.1365-2362.2009.02121.x

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