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  • Description:
  • Treatment with apelin‐13 significantly induces a downregulation of MMP‐9 expression in LSS‐ and OSS‐induced plaques and aortic sinus plaques. Quantification for MMP‐9 (immunostaining) in: OSS‐induced plaques (A: 3.602 ± 0.938 vs 1.249 ± 0.403, for vehicle and apelin‐13‐treated, respectively, P = .005); LSS‐induced plaques (D: 1.485 ± 0.306 vs 0.557 ± 0.284, for vehicle and apelin‐13‐treated, respectively, P = .035) and aortic sinus plaques (G: 4.126 ± 1.062 vs 1.746 ± 0.294, for vehicle and apelin‐13‐treated, respectively, P = .034) of apelin‐13‐ and vehicle‐treated ApoE−/− mice. Representative microphotographs show: OSS‐induced plaques (B,C); LSS‐induced plaques (E,F) and aortic sinus plaques (H,I). *P < .05 and **P < .01 (Mann‐Whitney nonparametric test). Data were expressed as mean ± SEM. OSS, oscillatory shear stress; LSS, low shear stress
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Copyright © 2018 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd
  • Asset Type:
  • Image
  • Asset Subtype:
  • Illustration
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 2128 x 1617
  • Image File Size:
  • 3.04 MB
  • Creator:
  • Rodrigo A. Fraga‐Silva, Hugo Seeman, Fabrizio Montecucco, Analina R. da Silva, Fabienne Burger, Fabiana P. Costa‐Fraga, Léa Anguenot, François Mach, Robson A. S. dos Santos, Nikolaos Stergiopulos, Rafaela F. da Silva
  • Credit:
  • Fraga‐Silva, R., Seeman, H., Montecucco, F., Linden, F., Domschke, G., Erbel, C., Akhavanpoor, M., Katus, H., Gleissner, C., Kolodgie, F., Gold, H., Burke, A., Yusuf, S., Reddy, S., Ounpuu, S., Anand, S., Schroeder, A., Falk, E., Spagnoli, L., Bonanno, E., Sangiorgi, G., Mauriello, A., Yu, X., Tang, Z., Liu, L., Dalzell, J., Rocchiccioli, J., Weir, R., Chun, H., Ali, Z., Kojima, Y., Liu, X., Lu, Q., Ouyang, X., Yao, F., Lv, Y., Zhang, M., Kadoglou, N., Sailer, N., Moumtzouoglou, A., Zhou, Y., Wang, Y., Qiao, S., Gunter, S., Solomon, A., Tsang, L., Cheng, C., Tempel, D., Haperen, R., Fraga‐Silva, R., Montecucco, F., Costa‐Fraga, F., Fraga‐Silva, R., Savergnini, S., Montecucco, F., Olivon, V., Fraga‐Silva, R., Segers, D., Fraga‐Silva, R., Costa‐Fraga, F., Montecucco, F., Silva, A., Fraga‐Silva, R., Stergiopulos, N., Montecucco, F., Mach, F., Koguchi, W., Kobayashi, N., Takeshima, H., Ishikawa, M., Sugiyama, F., Ishimitsu, T., Leeper, N., Tedesco, M., Kojima, Y., Hashimoto, T., Kihara, M., Imai, N., Ashley, E., Powers, J., & Chen, M. (2018). Apelin‐13 treatment enhances the stability of atherosclerotic plaques. European Journal of Clinical Investigation, 48(3), n/a-n/a. https://doi.org/10.1111/eci.12891.
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  • Keywords:
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  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Rodrigo A. Fraga‐Silva, Hugo Seeman, Fabrizio Montecucco, Analina R. da Silva, Fabienne Burger, Fabiana P. Costa‐Fraga, Léa Anguenot, François Mach, Robson A. S. dos Santos, Nikolaos Stergiopulos, Rafaela F. da Silva
  • Article Copyright Year:
  • 2018
  • Publication Volume:
  • 48
  • Publication Issue:
  • 3
  • Publication Date:
  • 03/01/2018
  • DOI:
  • https://doi.org/10.1111/eci.12891

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