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  • Description:
  • Apelin‐13 treatment reduces macrophage accumulation in LSS‐induced plaques. Quantification of macrophage infiltration (immunostaining for CD68) in: OSS‐induced plaques (A: 17.50 ± 2.643 vs 25.20 ± 2.967, for vehicle and apelin‐13‐treated, respectively, P = .054); LSS‐induced plaques (D: 8.712 ± 1.956 vs 2.749 ± 0.970, for vehicle and apelin‐13‐treated, respectively, P = .005) and aortic sinus plaques (G: 14.83 ± 1.188 vs 14.61 ± 0.945, for vehicle and apelin‐13‐treated, respectively, P = .8323) of apelin‐13‐ and vehicle‐treated ApoE−/− mice. Representative microphotographs show: OSS‐induced plaques (B,C); LSS‐induced plaques (E,F) and aortic sinus plaques (H,I). n.s.: nonsignificant and **P < .01 (Mann‐Whitney nonparametric test). Data were expressed as mean ± SEM. OSS, oscillatory shear stress; LSS, low shear stress
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • Copyright © 2018 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd
  • Asset Type:
  • Image
  • Asset Subtype:
  • Illustration
  • Image Orientation:
  • Landscape
  • Image Dimensions:
  • 2128 x 1664
  • Image File Size:
  • 3.54 MB
  • Creator:
  • Rodrigo A. Fraga‐Silva, Hugo Seeman, Fabrizio Montecucco, Analina R. da Silva, Fabienne Burger, Fabiana P. Costa‐Fraga, Léa Anguenot, François Mach, Robson A. S. dos Santos, Nikolaos Stergiopulos, Rafaela F. da Silva
  • Credit:
  • Fraga‐Silva, R., Seeman, H., Montecucco, F., Linden, F., Domschke, G., Erbel, C., Akhavanpoor, M., Katus, H., Gleissner, C., Kolodgie, F., Gold, H., Burke, A., Yusuf, S., Reddy, S., Ounpuu, S., Anand, S., Schroeder, A., Falk, E., Spagnoli, L., Bonanno, E., Sangiorgi, G., Mauriello, A., Yu, X., Tang, Z., Liu, L., Dalzell, J., Rocchiccioli, J., Weir, R., Chun, H., Ali, Z., Kojima, Y., Liu, X., Lu, Q., Ouyang, X., Yao, F., Lv, Y., Zhang, M., Kadoglou, N., Sailer, N., Moumtzouoglou, A., Zhou, Y., Wang, Y., Qiao, S., Gunter, S., Solomon, A., Tsang, L., Cheng, C., Tempel, D., Haperen, R., Fraga‐Silva, R., Montecucco, F., Costa‐Fraga, F., Fraga‐Silva, R., Savergnini, S., Montecucco, F., Olivon, V., Fraga‐Silva, R., Segers, D., Fraga‐Silva, R., Costa‐Fraga, F., Montecucco, F., Silva, A., Fraga‐Silva, R., Stergiopulos, N., Montecucco, F., Mach, F., Koguchi, W., Kobayashi, N., Takeshima, H., Ishikawa, M., Sugiyama, F., Ishimitsu, T., Leeper, N., Tedesco, M., Kojima, Y., Hashimoto, T., Kihara, M., Imai, N., Ashley, E., Powers, J., & Chen, M. (2018). Apelin‐13 treatment enhances the stability of atherosclerotic plaques. European Journal of Clinical Investigation, 48(3), n/a-n/a. https://doi.org/10.1111/eci.12891.
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  • Keywords:
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  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Rodrigo A. Fraga‐Silva, Hugo Seeman, Fabrizio Montecucco, Analina R. da Silva, Fabienne Burger, Fabiana P. Costa‐Fraga, Léa Anguenot, François Mach, Robson A. S. dos Santos, Nikolaos Stergiopulos, Rafaela F. da Silva
  • Article Copyright Year:
  • 2018
  • Publication Volume:
  • 48
  • Publication Issue:
  • 3
  • Publication Date:
  • 03/01/2018
  • DOI:
  • https://doi.org/10.1111/eci.12891

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