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  • Description:
  • Chronic intermittent hypobaric hypoxia (CIHH) preserved Ca‐handling protein expression. (A, B) Myocardial ischaemia up‐regulated RyR and SERCA2a mRNA expression in normoxic rats; CIHH up‐regulated RyR and SERCA2a mRNA expression under normal conditions, but maintained it at the similar level during ischaemia. Stimulation or inhibition of TSPO did not promote the ischaemic modification of RyR and SERCA2a both in normoxic and CIHH rats. (C) Myocardial ischaemia did not change CASQ mRNA expression in normoxic rat. CIHH up‐regulated CASQ mRNA expression under basal conditions and maintained it at a similar level during myocardial ischaemia. RyR: ryanodine receptor; SERCA2a: Ca‐ATPase; CASQ: calsequestrin; Ctrl: control; Isch: ischaemia; DZP: 4′‐Cl‐DZP; *P < 0.05, **P < 0.01).
  • License:
  • Rights Managed
  • Rights Holder:
  • John Wiley & Sons, Inc.
  • License Rights Holder:
  • © 2011 The Author Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd
  • Asset Type:
  • Image
  • Asset Subtype:
  • Chart/Graph
  • Image Orientation:
  • Portrait
  • Image Dimensions:
  • x
  • Image File Size:
  • 80 KB
  • Creator:
  • Jun Li, Jiahong Xu, Junjie Xiao, Hong Zhang, Dandan Liang, Yi Liu, Yangyang Zhang, Ying Liu, Wei Wen, Yaer Hu, Zhuo Yu, Biao Yan, Bing Jiang, Zhao‐Nian Zhou, Yi‐Han Chen
  • Credit:
  • Li, J., Xu, J., Xiao, J., Zhang, H., Liang, D., Liu, Y., Zhang, Y., Liu, Y., Wen, W., Hu, Y., Yu, Z., Yan, B., Jiang, B., Zhou, Z.-N., & Chen, Y.-H. (2011). Preservation of TSPO by chronic intermittent hypobaric hypoxia confers antiarrhythmic activity. Journal of Cellular and Molecular Medicine, 15(1), 134-140. https://doi.org/10.1111/j.1582-4934.2009.00949.x.
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  • Keywords:
  • Restrictions:
  • Property Release:
  • No
  • Model Release:
  • No
  • Purchasable:
  • Yes
  • Sensitive Materials:
  • No
  • Article Authors:
  • Jun Li, Jiahong Xu, Junjie Xiao, Hong Zhang, Dandan Liang, Yi Liu, Yangyang Zhang, Ying Liu, Wei Wen, Yaer Hu, Zhuo Yu, Biao Yan, Bing Jiang, Zhao‐Nian Zhou, Yi‐Han Chen
  • Article Copyright Year:
  • 2011
  • Publication Volume:
  • 15
  • Publication Issue:
  • 1
  • Publication Date:
  • 01/01/2011
  • DOI:
  • https://doi.org/10.1111/j.1582-4934.2009.00949.x

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