Advanced Search
Displaying assets from 1 to 30 out of 6
-
Description SDS gels showing correct formation of native Ibα‐Ibβ disulfide bonds in the Ibα/Ibβ/HA‐IbβEabc‐IXTC complex. Lysates from various transfected CHO cells were separated in Bis‐Tris SDS gels under...
Article Title: Analysis of inter‐subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib‐IX complex
Publication Title: Journal of Thrombosis and Haemostasis -
Description Replacing IXE in GPIb‐IX with IbβEabc significantly decreases surface expression of Ibα in transiently transfected CHO cells. (A) Sketches of the mutant GPIb‐IX complex containing IbβEabc‐IXTC in...
Article Title: Analysis of inter‐subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib‐IX complex
Publication Title: Journal of Thrombosis and Haemostasis -
Description The organization of the GPIb‐IX complex, viewed from the extracellular space towards the membrane, is summarized in a sketch for easy visualization and comprehension. (A) The membrane‐proximal...
Article Title: Analysis of inter‐subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib‐IX complex
Publication Title: Journal of Thrombosis and Haemostasis -
Description SDS gels showing the effect of domain replacement on the expression and Ibα‐Ibβ disulfide formation in various transfected CHO cells. Lysates from various CHO cells transfected with GPIb‐IX...
Article Title: Analysis of inter‐subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib‐IX complex
Publication Title: Journal of Thrombosis and Haemostasis -
Description Extracellular domains of Ibβ and IX adopt different conformations to stabilize certain domain‐swapped GPIb‐IX complexes and enhance their surface expression. (A) Sketches of wild‐type GPIb‐IX and...
Article Title: Analysis of inter‐subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib‐IX complex
Publication Title: Journal of Thrombosis and Haemostasis -
Description Reduced surface expression of Ibα is due to the reduced expression of Ibβ in the Ibα/Ibβ/HA‐IbβEabc‐IXTC complex. (A) Sketches of mutant GPIb‐IX complexes used. The style follows that described in...
Article Title: Analysis of inter‐subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib‐IX complex
Publication Title: Journal of Thrombosis and Haemostasis