Description A proposed mechanism of cell protection by tissue plasminogen activator (tPA) antagonism. The proteolytic cleavage of a putative target (e.g., NMDA receptor) by tPA induces cell apoptosis and/or...
Article Title: Antifibrinolytic agents reduce tissue plasminogen activator‐mediated neuronal toxicity in vitro
Publication Title: Acta Anaesthesiologica Scandinavica

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Description Time effects of tissue plasminogen activator (tPA) treatment on N27 cell viability. N27 cell viability after tPA treatment (10–20 μg/ml) for various durations in a medium containing 2% serum (upper...
Article Title: Antifibrinolytic agents reduce tissue plasminogen activator‐mediated neuronal toxicity in vitro
Publication Title: Acta Anaesthesiologica Scandinavica

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Description Effects of various protease inhibitors on tissue plasminogen activator (tPA)‐induced N27 cell death. Effects of protease inhibitors on N27 cell death due to tPA treatment (10–20 μg/ml) in...
Article Title: Antifibrinolytic agents reduce tissue plasminogen activator‐mediated neuronal toxicity in vitro
Publication Title: Acta Anaesthesiologica Scandinavica

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Description Flowcytometric analysis of N27 cells before and after tissue plasminogen activator (tPA) treatment. DNA (G0/G1and G2 phases) content of untreated and tPA‐treated N 27 cells grown in culture. (A)...
Article Title: Antifibrinolytic agents reduce tissue plasminogen activator‐mediated neuronal toxicity in vitro
Publication Title: Acta Anaesthesiologica Scandinavica

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Description Effects of aprotinin on tissue plasminogen activator (tPA)‐induced N27 cell death. Aprotinin reduces N27 cell death due to tPA treatment in serum‐free media. Cultured cells were treated with...
Article Title: Antifibrinolytic agents reduce tissue plasminogen activator‐mediated neuronal toxicity in vitro
Publication Title: Acta Anaesthesiologica Scandinavica

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