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Description Abc metabolizing enzymes are not expressed in immune cells of peripheral blood. (A) mRNA from PBMCs, EBV‐BLCLs, monocytes, DCs, abc‐TCC‐A1/HD543 (TCC A1), and abc‐TCC‐D1/HD543 (TCC D1) was reverse...
Article Title: Avidity determines T‐cell reactivity in abacavir hypersensitivity
Publication Title: European Journal of Immunology -
Description Duration of abc‐pulsing affects IA‐TCC activation patterns. HA‐TCC‐17D/HD589, IA‐TCC‐15A/HD589, and LA‐TCC‐21C/HD589 were stimulated with APCs, pulsed with abc for 2 h, 1 h, or 15 min and specific...
Article Title: Avidity determines T‐cell reactivity in abacavir hypersensitivity
Publication Title: European Journal of Immunology -
Description Abc‐specific TCCs exhibit different abc recognition patterns. Forty‐seven TCCs were analyzed in a Ca2+ influx assay for their abc recognition patterns. (A) TCC‐2D/HD589, ‐6B/HD543, and ‐11C/HD588...
Article Title: Avidity determines T‐cell reactivity in abacavir hypersensitivity
Publication Title: European Journal of Immunology -
Description TCC activation patterns are defined by abc concentration. (A) TCC‐2D/HD589 was stimulated with decreasing concentrations of abc in solution (10–0.01 μg/mL) in the presence of APCs (left). TCCs...
Article Title: Avidity determines T‐cell reactivity in abacavir hypersensitivity
Publication Title: European Journal of Immunology -
Description Antigen density on APCs influences abc‐specific TCC reactivity patterns. (A) HLA‐B*5701‐transduced 721.221 cells were quantified for their HLA‐B*5701 and β2‐microglobulin surface expression....
Article Title: Avidity determines T‐cell reactivity in abacavir hypersensitivity
Publication Title: European Journal of Immunology -
Description Specific TCCs exhibit different TCR avidities for abc. (A) TCC‐2D/HD589 was stimulated with the indicated concentrations of abc in solution in the presence of APCs for 4 h. TCC activation was...
Article Title: Avidity determines T‐cell reactivity in abacavir hypersensitivity
Publication Title: European Journal of Immunology