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Description Contribution of serum and LBP to TLR2 activation by F. tularensis. HeLa‐TLR2 cells, transiently transfected with ELAM‐luciferase reporter construct, CMV‐CD14, and CMV‐β‐Gal (for normalization),...
Article Title: Innate immune response to Francisella tularensis is mediated by TLR2 and caspase‐1 activation
Publication Title: Journal of Leukocyte Biology -
Description Cytokine and chemokine induction by F. tularensis is mediated by TLR2. DC derived from the bone marrow of TLR2‐deficient mice or wild‐type (WT) littermates were stimulated with the indicated...
Article Title: Innate immune response to Francisella tularensis is mediated by TLR2 and caspase‐1 activation
Publication Title: Journal of Leukocyte Biology -
Description IL‐1β secretion is induced by live but not heat‐killed F. tularensis. Human (A) and mouse (B) DC were stimulated with the indicated agonists for 20 h, and cytokine levels were measured in...
Article Title: Innate immune response to Francisella tularensis is mediated by TLR2 and caspase‐1 activation
Publication Title: Journal of Leukocyte Biology -
Description Comparison of cytokine and chemokine induction by different TLR agonists and F. tularensis in human DC and PBMC. Human immature DC (A) and PBMC (B) were stimulated with the indicated agonists for 5...
Article Title: Innate immune response to Francisella tularensis is mediated by TLR2 and caspase‐1 activation
Publication Title: Journal of Leukocyte Biology -
Description Cytokine and chemokine induction by F. tularensis is not mediated by TLR4. The mouse macrophage cell lines HeNC2 (wild‐type) and GG2EE (TLR4‐deficient) were stimulated with the indicated agonists...
Article Title: Innate immune response to Francisella tularensis is mediated by TLR2 and caspase‐1 activation
Publication Title: Journal of Leukocyte Biology -
Description TLR2 activation by F. tularensis does not require LBP and occurs through TLR2/TLR1 and TLR2/TLR6 heterodimers. HeLa cell lines expressing the indicated TLR constructs were transiently transfected...
Article Title: Innate immune response to Francisella tularensis is mediated by TLR2 and caspase‐1 activation
Publication Title: Journal of Leukocyte Biology