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Description Cell viability studies. Outcome of compound D19 and D22 treatment on the viabilities of HEK293 and HepG2 cells. Cells were treated with increasing concentrations of compounds D19 and D22 for 48 h....
Article Title: Pharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors
Publication Title: ChemistrySelect -
Description Fluorescence binding study of compound D12 withthe CaMKIV (A) Fluorescence spectra of CaMKIV (6 μM) with increasing concentrations of ligand 2.5, 5, 7.5, 10, 12.5, 15, 17.5, 20, 22.5 μM (from top...
Article Title: Pharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors
Publication Title: ChemistrySelect -
Description Apoptosis studies. (A) Annexin‐V staining of HepG2 cells; cells were incubated with IC50 concentrations of compounds D19 and D22 for 48 h. Cells were stained with FITC labelled Annexin‐V and...
Article Title: Pharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors
Publication Title: ChemistrySelect -
Description Binding parameters of CaMKIV‐ligand interaction.
Article Title: Pharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors
Publication Title: ChemistrySelect -
Description Fluorescence binding study of compound D22 with the CaMKIV (A). Fluorescence spectra of CaMKIV (6 μM) with increasing concentrations of 2.5, 5, 7.5, 10, 12.5, 15, 17.5, 20 μM (from top to bottom)...
Article Title: Pharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors
Publication Title: ChemistrySelect -
Description Synthetic route for the target compounds (D1‐D24). Reagents and conditions: (i) salicylaldehyde, nitrostyrene and DABCO at 40 0C; (ii) nitrochromene, aniline and KOtBu in DMF at room temperature.
Article Title: Pharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors
Publication Title: ChemistrySelect -
Description ORTEP diagram of product D2.
Article Title: Pharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors
Publication Title: ChemistrySelect -
Description Molecular docking studies of selected compounds with CAMKIV: Three‐dimensional focused view of CAMKIV binding pocket with (A) compound D19, (C) compound D22 shows the hydrogen bond donor‐acceptor...
Article Title: Pharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors
Publication Title: ChemistrySelect -
Description Fluorescence binding study of compound D19 with the CaMKIV (A) Fluorescence spectra of CaMKIV (6 μM) with increasing concentrations of ligand 2.5, 5, 7.5, 10, 12.5, 15, 17.5, 20 μM (from top to...
Article Title: Pharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors
Publication Title: ChemistrySelect -
Description CAMKIV enzyme activity profile of selected compounds: (A) Standard phosphate hydrolysis curve; used to quantify the hydrolyzed phosphate released as a result of kinase activity of CAMKIV; (B)...
Article Title: Pharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors
Publication Title: ChemistrySelect