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Description Individual venetoclax Cmax and AUC∞ values after administration of 50 mg venetoclax alone on Day 1 and after coadministration with 400 mg ketoconazole on Day 8 (n = 11). *Red line denotes the...
Article Title: Effect of ketoconazole, a strong CYP3A inhibitor, on the pharmacokinetics of venetoclax, a BCL‐2 inhibitor, in patients with non‐Hodgkin lymphoma
Publication Title: British Journal of Clinical Pharmacology -
Description Absolute risk of an injurious fall per day for the use of SSRIs and hypnotics or sedatives
Article Title: Dose–response relationship between selective serotonin re‐uptake inhibitors and injurious falls: a study in nursing home residents with dementia
Publication Title: British Journal of Clinical Pharmacology -
Description Neopterin concentration−time profiles stratified by antibody status in patients with sparse sampling only. Data from every 2 weeks and every 4 weeks groups at weeks 4, 12, 24, 48, 56 and 84 were...
Article Title: Pharmacokinetics and pharmacodynamics of peginterferon beta‐1a in patients with relapsing‐remitting multiple sclerosis in the randomized ADVANCE study
Publication Title: British Journal of Clinical Pharmacology -
Description Comparison of main patients' characteristics at baseline (n = 42)
Article Title: Clinical and pharmacokinetics equivalence of multiple doses of levodopa benserazide generic formulation vs the originator (Madopar)
Publication Title: British Journal of Clinical Pharmacology -
Description Influence of smoking and gender on the excretion of ebastine, measured as µmols of metabolites in urine, in Caucasian healthy subjects. Values are mean ± SD (95% CI)
Article Title: The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 C3435T polymorphisms and gender on the urinary excretion of the metabolites of the H1‐receptor antihistamine ebastine: a pilot study
Publication Title: British Journal of Clinical Pharmacology -
Description Age groups: the distribution of patients in the cohort in six age groups. Median age was 69 years (range 48–91 years)
Article Title: Drug–drug interaction potential in men treated with enzalutamide: Mind the gap
Publication Title: British Journal of Clinical Pharmacology -
Description Formula for calculation of MPR
Article Title: Does tablet formulation alone improve adherence and persistence: a comparison of ezetimibe fixed dose combination versus ezetimibe separate pill combination?
Publication Title: British Journal of Clinical Pharmacology -
- Identifier
- bcp13131-fig-0004
- License Type
- CC-BY-NC-ND
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Model‐predicted total clearance of daptomycin in different patient populations. Note: Three patients in whom it was unknown whether or not they were on dialysis were excluded from this analysis....
Article Title: Population pharmacokinetics of daptomycin in adult patients undergoing continuous renal replacement therapy
Publication Title: British Journal of Clinical Pharmacology -
Description Forest plot detailing weighted mean difference and 95% confidence intervals (CIs) for the impact of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on plasma high‐sensitivity...
Article Title: Effect of monoclonal antibodies to PCSK9 on high‐sensitivity C‐reactive protein levels: a meta‐analysis of 16 randomized controlled treatment arms
Publication Title: British Journal of Clinical Pharmacology -
Description Interventional studies of xanthine oxidase inhibiton in patients with or at risk of cardiovascular disease
Article Title: Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease?
Publication Title: British Journal of Clinical Pharmacology -
Description (A) Model analysis of ketoprofen plasma concentration profiles in rat mothers and fetuses. Each point represents the mean ± standard error (SE) (n = 3). (B) Ductus arteriosus/pulmonary artery...
Article Title: Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data
Publication Title: British Journal of Clinical Pharmacology -
Description The different modes of action for therapeutic oligonucleotides. A) Activation or inhibition of the target protein to induce or inhibit immune activation. B) Exon skipping to induce alternative...
Article Title: Injection site reactions after subcutaneous oligonucleotide therapy
Publication Title: British Journal of Clinical Pharmacology -
Description Characteristics of the 23 HIV‐infected children
Article Title: Population pharmacokinetics and maximum a posteriori probability Bayesian estimator of abacavir: application of individualized therapy in HIV‐infected infants and toddlers
Publication Title: British Journal of Clinical Pharmacology -
Description Pharmacokinetic parameters estimates for the final model
Article Title: Toward a robust tool for pharmacokinetic‐based personalization of treatment with tacrolimus in solid organ transplantation: A model‐based meta‐analysis approach
Publication Title: British Journal of Clinical Pharmacology -
Description Bland–Altman comparison of the concentrations measured by the liquid chromatography tandem mass spectrometry (LC–MS/MS) assay and anti‐Xa activity at the trough steady state after rivaroxaban...
Article Title: Factor Xa inhibition by rivaroxaban in the trough steady state can significantly reduce thrombin generation
Publication Title: British Journal of Clinical Pharmacology -
Description Distribution of various characteristics between patients receiving different classes of lipid‐lowering drug therapy and the relevant odds ratio for treatment initiation.
Article Title: Who receives lipid‐lowering drugs: the effects of comorbidities and patient characteristics on treatment initiation
Publication Title: British Journal of Clinical Pharmacology -
Description Mean serum creatinine in co‐trimoxazole and placebo arms. The illustrated error bars depict the standard error for each measurement
Article Title: The effect of co‐trimoxazole on serum potassium concentration: safety evaluation of a randomized controlled trial
Publication Title: British Journal of Clinical Pharmacology -
- Identifier
- bcp13357-fig-0007
- License Type
- CC-BY-NC
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Effects of varying water volume in the tissue compartment bottle on plasma concentration–time profiles following intravenous administration in a two‐compartment configuration. Calculated...
Article Title: ADAM, a hands‐on patient simulator for teaching principles of drug disposition and compartmental pharmacokinetics
Publication Title: British Journal of Clinical Pharmacology -
Description Effect of renal impairment on simulated steady‐state exposure with omarigliptin 25‐mg once‐weekly administration in patients with type 2 diabetes. Boxes are 25th, 50th and 75th percentiles....
Article Title: Pharmacokinetic–pharmacodynamic (dipeptidyl peptidase‐4 inhibition) model to support dose rationale in diabetes patients, including those with renal impairment, for once‐weekly administered omarigliptin
Publication Title: British Journal of Clinical Pharmacology -
Description Some journals on which UK clinical pharmacologists have or have had editorial duties
Article Title: What do clinical pharmacologists do? A questionnaire survey of senior UK clinical pharmacologists
Publication Title: British Journal of Clinical Pharmacology -
Description Top five prescribed oral herbal remedies
Article Title: Homoeopathic and herbal prescribing in general practice in Scotland
Publication Title: British Journal of Clinical Pharmacology -
Description Pharmacokinetic variables of 20 mg quazepam to 9 healthy volunteers with no food and 30 min and 3 h after food intake.
Article Title: Time effects of food intake on the pharmacokinetics and pharmacodynamics of quazepam
Publication Title: British Journal of Clinical Pharmacology -
Description Primary and secondary analysis. AFCAPS/TexCAPS, Air Force/Texas Coronary Atherosclerosis Prevention Study; CARDS, Collaborative Atorvastatin Diabetes Study; GISSI‐HF, Gruppo Italiano per lo Studio...
Article Title: Myopathy in older people receiving statin therapy: a systematic review and meta‐analysis
Publication Title: British Journal of Clinical Pharmacology -
Description Toxicology of cilomilast
Article Title: An update and appraisal of the cilomilast Phase III clinical development programme for chronic obstructive pulmonary disease
Publication Title: British Journal of Clinical Pharmacology -
Description Risk factors and medical history in employed persons who submitted a claim for reimbursement* of a nonsteroidal anti‐inflammatory drug prescription in France 2003–2004 (n = 5651)
Article Title: The CADEUS study: burden of nonsteroidal anti‐inflammatory drug (NSAID) utilization for musculoskeletal disorders in blue collar workers
Publication Title: British Journal of Clinical Pharmacology -
Description Patient demographics (25 patients)
Article Title: A Bayesian approach for population pharmacokinetic modelling of sirolimus
Publication Title: British Journal of Clinical Pharmacology -
Description Study flow chart. AST: aspartate aminotransferase; NSAIDs: nonsteroidal anti‐inflammatory drugs
Article Title: Randomized, controlled, multicentre clinical trial of the antipyretic effect of intravenous paracetamol in patients admitted to hospital with infection
Publication Title: British Journal of Clinical Pharmacology -
Description (A) Mean plasma concentrations of sitaxsentan after oral administration of single 100‐mg doses to subjects with normal and impaired renal function; semilogarithmic axes. (B) Relationship between...
Article Title: The pharmacokinetic profile of sitaxsentan, a selective endothelin receptor antagonist, in varying degrees of renal impairment
Publication Title: British Journal of Clinical Pharmacology -
Description Neurotransmitter sites affected by clozapine, quetiapine, and their major metabolites
Article Title: An agenda for UK clinical pharmacology: From basic to clinical neuropharmacology: targetophilia or pharmacodynamics?
Publication Title: British Journal of Clinical Pharmacology -
Description Comparison of estimated Cmax,ss, Cmin,ss and AUCss (normalized to 20 mg dose level) between ovarian and nonovarian cancer patients
Article Title: Population pharmacokinetic and exposure simulation analysis for cediranib (AZD2171) in pooled Phase I/II studies in patients with cancer
Publication Title: British Journal of Clinical Pharmacology