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Description Estimated pharmacokinetic parameters
Article Title: Influence of methotrexate on infliximab pharmacokinetics and pharmacodynamics in ankylosing spondylitis
Publication Title: British Journal of Clinical Pharmacology -
Description Demography of cancer and noncancer patient groups.
Article Title: Phenotyping CYP3A using midazolam in cancer and noncancer Asian patients
Publication Title: British Journal of Clinical Pharmacology -
Description Steady‐state mean voriconazole and voriconazole N‐oxide plasma concentration vs. time profiles following administration of voriconazole alone (day 4) or in combination with oral contraceptive (day...
Article Title: Pharmacokinetics and tolerability of voriconazole and a combination oral contraceptive co‐administered in healthy female subjects
Publication Title: British Journal of Clinical Pharmacology -
Description Cardiovascular safety of novel oral anticoagulants: ranking histograms generated by Bayesian probabilistic analysis. The clinical material (27 randomized trials; four treatments; 137 484 patients)...
Article Title: Cardiovascular safety of new oral anticoagulants: re‐analysis of 27 randomized trials based on Bayesian network meta‐analysis
Publication Title: British Journal of Clinical Pharmacology -
Description Summary of transporters expressed in human hepatocytes involved in mediating drug uptake and efflux (A), and illustration of the impact of SLCO1B1 genetic variation on drug disposition in vivo (B)....
Article Title: Interindividual and interethnic variability in drug disposition: polymorphisms in organic anion transporting polypeptide 1B1 (OATP1B1; SLCO1B1)
Publication Title: British Journal of Clinical Pharmacology -
Description Prisma flow chart GORD, gastro‐oesophageal reflux disease; PPI, proton pump inhibitor
Article Title: Comparing intravenous and oral proton pump inhibitor therapy for bleeding peptic ulcers following endoscopic management: a systematic review and meta‐analysis
Publication Title: British Journal of Clinical Pharmacology -
- Identifier
- bcp12432-fig-0005
- License Type
- CC-BY-NC-ND
- Rights Holder
- Creative Commons by John Wiley & Sons
Description Aspirin stimulates endogenous MRP4 expression in megakaryocytes. (A) Q‐RT‐PCR analysis of endogenous MRP4 and PPARα expression in MKs, derived from HPC grown, in mock culture (Ctr), and grown the...
Article Title: Aspirin influences megakaryocytic gene expression leading to up‐regulation of multidrug resistance protein‐4 in human platelets
Publication Title: British Journal of Clinical Pharmacology -
Description Critical flicker fusion – between‐treatment differences in change from baseline after administration of gaboxadol 10 mg, zolpidem 5 mg, and placebo (n = 22)
Article Title: Tolerability, pharmacokinetics and night‐time effects on postural sway and critical flicker fusion of gaboxadol and zolpidem in elderly subjects
Publication Title: British Journal of Clinical Pharmacology -
Description Base models for S‐ and R‐warfarin
Article Title: The population pharmacokinetics of R‐ and S‐warfarin: effect of genetic and clinical factors
Publication Title: British Journal of Clinical Pharmacology -
Description Observed and predicted DAS28 change from baseline vs. time, by treatment. The light grey dashed lines and symbols represent individual patient response profiles, and solid lines represent the...
Article Title: Comparative assessment of clinical response in patients with rheumatoid arthritis between PF‐05280586, a proposed rituximab biosimilar, and rituximab
Publication Title: British Journal of Clinical Pharmacology -
Description Type of gastroprotective strategy in high‐risk patients per year. H2RA, histamine‐2 receptor antagonist; LDA, low‐dose aspirin; NSAID, non‐steroidal anti‐inflammatory drug; PPI, proton pump inhibitor
Article Title: Time‐trends in the prescribing of gastroprotective agents to primary care patients initiating low‐dose aspirin or non‐steroidal anti‐inflammatory drugs: a population‐based cohort study
Publication Title: British Journal of Clinical Pharmacology -
Description Predictive performance of the final population PK model for the index data set and for the naive predictor.
Article Title: Population pharmacokinetics and concentration–effect relationships of capecitabine metabolites in colorectal cancer patients
Publication Title: British Journal of Clinical Pharmacology -
Description Primary and secondary analysis. AFCAPS/TexCAPS, Air Force/Texas Coronary Atherosclerosis Prevention Study; CARDS, Collaborative Atorvastatin Diabetes Study; GISSI‐HF, Gruppo Italiano per lo Studio...
Article Title: Myopathy in older people receiving statin therapy: a systematic review and meta‐analysis
Publication Title: British Journal of Clinical Pharmacology -
Description Characteristics of total study population and groups defined by age
Article Title: Pulse pressure amplification in relation to body fatness
Publication Title: British Journal of Clinical Pharmacology -
Description Flow chart of the number of studies identified and included in the meta‐analysis
Article Title: Impact of statin therapy on plasma leptin concentrations: a systematic review and meta‐analysis of randomized placebo‐controlled trials
Publication Title: British Journal of Clinical Pharmacology -
Description Forest plot of comparison between oral and IV PPIs for (A) need for surgery, (B) mortality and (C) EHT, need for a second endoscopic treatment. CI, confidence interval; IV, intravenous; M‐H,...
Article Title: Comparing intravenous and oral proton pump inhibitor therapy for bleeding peptic ulcers following endoscopic management: a systematic review and meta‐analysis
Publication Title: British Journal of Clinical Pharmacology -
Description Proportion of patients exceeding (in the beneficial direction) a threshold abatement in rate of decline, over a range of threshold values. As shown in Table S5, these estimated proportions do not...
Article Title: Quantitative disease progression model of α‐1 proteinase inhibitor therapy on computed tomography lung density in patients with α‐1 antitrypsin deficiency
Publication Title: British Journal of Clinical Pharmacology -
Description (A) Erb's point evoked potentials. The figure shows only the data up to 15 ms as this time interval includes the main peak, and cutting it down to this time interval (i.e. zooming in on the peak)...
Article Title: Venlafaxine and oxycodone have different effects on spinal and supraspinal activity in man: a somatosensory evoked potential study
Publication Title: British Journal of Clinical Pharmacology -
Description Pre‐existing anti‐idarucizumab responses in plasma from treatment‐naïve individuals from the three Phase I studies evaluated. (A) blocking of ADA assay responses by idarucizumab, (B) blocking of...
Article Title: Evaluation of the immunogenicity of the dabigatran reversal agent idarucizumab during Phase I studies
Publication Title: British Journal of Clinical Pharmacology -
Description Summary of primer pairs [wild‐type (WT) or mutant (MT) and common (CM) primers] and TaqMan probe (TM) sequences (5’−3’).
Article Title: Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR‐1 in the Egyptian population
Publication Title: British Journal of Clinical Pharmacology -
Description Antipsychotic poisoning admissions to Edinburgh Royal Infirmary
Article Title: Effects of licence change on prescribing and poisons enquiries for antipsychotic agents in England and Scotland
Publication Title: British Journal of Clinical Pharmacology -
Description England TOXBASE enquiries
Article Title: Effects of licence change on prescribing and poisons enquiries for antipsychotic agents in England and Scotland
Publication Title: British Journal of Clinical Pharmacology -
Description Major vascular outcomes and all cause mortality
Article Title: Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials
Publication Title: British Journal of Clinical Pharmacology -
Description Cumulative cost per person (AUS$) for (A) medication and (B) medical services. 1, Start of patient enrolments; 2, start of home visits; 3, start of medication reviews; 4, Start of Primary Health...
Article Title: Medication reviews in the community: results of a randomized, controlled effectiveness trial
Publication Title: British Journal of Clinical Pharmacology -
Description Correlation between baseline estimated glomerular filtration rate (eGFR) (A) and cytochrome B450 2C19 genotype (B) and 30‐day inhibition of platelet aggregation in non‐ST‐elevation acute coronary...
Article Title: Pharmacodynamics and pharmacokinetics of ticagrelor vs. clopidogrel in patients with acute coronary syndromes and chronic kidney disease
Publication Title: British Journal of Clinical Pharmacology -
Description Demographic details
Article Title: Vancomycin is commonly under‐dosed in critically ill children and neonates
Publication Title: British Journal of Clinical Pharmacology -
Description Gender difference of CYP3A activity (mean ± SD)
Article Title: The distribution and gender difference of CYP3A activity in Chinese subjects
Publication Title: British Journal of Clinical Pharmacology -
Description Examples of different sources of medicines information
Article Title: An agenda for UK clinical pharmacology: Provision of medicines information: the example of the British National Formulary
Publication Title: British Journal of Clinical Pharmacology -
Description Mean and 95% confidence limits of the heart rate (HR) during the study. *P < 0.01 compared with the value at the 20th min in the same group; †P < 0.05 compared with initial value in the same group;...
Article Title: Small doses of droperidol do not present relevant torsadogenic actions: a double‐blind, ondansetron‐controlled study
Publication Title: British Journal of Clinical Pharmacology -
Description Relationship between Bayesian estimates of oral clearance (CL/F) of alogliptin and body weight. • post hoc estimate of CL/F; weight on CL/F as a power function
Article Title: Application of pharmacometric approaches to evaluate effect of weight and renal function on pharmacokinetics of alogliptin
Publication Title: British Journal of Clinical Pharmacology