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Displaying assets from 1 to 30 out of 1871
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Description A) Synthesis of 2,4,6‐functionalized pyrimidines by condensation of urea/guanidine and malonic acid during environmental cycles under prebiotic conditions. B) Cocrystals of barbituric acid and...
Article Title: Prebiotic Origin of Pre‐RNA Building Blocks in a Urea “Warm Little Pond” Scenario
Publication Title: ChemBioChem -
Description Reaction mechanism between 3‐isocyanpropyl derivatives and tetrazines. Following cycloaddition and the expulsion of nitrogen gas, tautomerization of the 4H‐pyrazole species to form the aromatic...
Article Title: Dissociative Bioorthogonal Reactions
Publication Title: ChemBioChem -
Description Substrate scope of concurrent photo‐biocatalytic oxidation and alkylation reactions [0.3 m substrate, 2 mol % Ru(bpy)3Cl2⋅6 H2O, 0.16 mol % WGL, irradiation with 32 W compact fluorescent lamp (CFL)...
Article Title: Biocatalysis Fueled by Light: On the Versatile Combination of Photocatalysis and Enzymes
Publication Title: ChemBioChem -
Description A three‐step strategy (marking/activation/coupling) that is applicable to the generation of authentic PTMs in proteins. The modification site can be marked with Sep by using a Sep‐incorporation...
Article Title: Noncanonical Amino Acids in Synthetic Biosafety and Post‐translational Modification Studies
Publication Title: ChemBioChem -
Description Synthesis of Auh‐containing peptides and Aub‐containing peptides.
Article Title: Effects of Arginine Deimination and Citrulline Side‐Chain Length on Peptide Secondary Structure Formation
Publication Title: ChemBioChem -
Description Synthesis of N‐glycan 3, deprotection to hemiacetal 4 and enzymatic galactosylation to 5 and 6. The numbering of the residues for NMR assignments is shown for 6.
Article Title: Efficient Chemoenzymatic Synthesis of N‐Glycans with a β1,4‐Galactosylated Bisecting GlcNAc Motif
Publication Title: ChemBioChem -
Description Catechol assembly strategies.
Article Title: Expanding the DOPA Universe with Genetically Encoded, Mussel‐Inspired Bioadhesives for Material Sciences and Medicine
Publication Title: ChemBioChem -
Description Structures of monomers (unnatural amino acids; non‐proteinogenic amino acids) presented herein.
Article Title: Cell‐Penetrating Peptide Foldamers: Drug‐Delivery Tools
Publication Title: ChemBioChem -
Description On the Case of the Misplaced Hydrogens - ChemBioChemChemBioChem vol. 22, January 15, 2021
Article Title: On the Case of the Misplaced Hydrogens
Publication Title: ChemBioChem -
Description Interprobe distances for F0T8‐OMe and F0T8‐ol as a function of increasing temperature.
Article Title: A Temperature‐Driven, Reversible, Helical‐Handedness Inversion in Peptaibol Analogues Tuned by the C‐Terminal Capping Moiety
Publication Title: ChemBioChem -
Description Steady‐state kinetic data for wild‐type X. campestris OleC and variants measured using the spectrophotometric assay and fit with the Michaelis–Menten equation. Mean±s.d.
Article Title: Mechanism of a Standalone β‐Lactone Synthetase: New Continuous Assay for a Widespread ANL Superfamily Enzyme
Publication Title: ChemBioChem -
Description Number of NMR and X‐ray cyclotide structures for which coordinates have been deposited in the PDB.
Article Title: Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography
Publication Title: ChemBioChem -
Description i) BF3⋅OEt2, CH2Cl2, 0 °C–RT, 1 h, 78 %; ii) 10, N‐iodosuccinimide (NIS), silver trifluoromethanesulfonate (AgOTf), RT, 1 h, 69 %; iii) NaOMe, MeOH/THF, RT, 12 h, 90 %.
Article Title: Mannopyranoside Glycolipids Inhibit Mycobacterial and Biofilm Growth and Potentiate Isoniazid Inhibition Activities in M. smegmatis
Publication Title: ChemBioChem -
Description Results of the second round of HGG evolution.
Article Title: Hemoprotein‐Catalyzed Cyclopropanation En Route to the Chiral Cyclopropanol Fragment of Grazoprevir
Publication Title: ChemBioChem -
Description Enhancing Biosynthesis and Manipulating Flux in Whole Cells with Abiotic Catalysis - ChemBioChemChemBioChem vol. 22, February 2, 2021
Article Title: Enhancing Biosynthesis and Manipulating Flux in Whole Cells with Abiotic Catalysis
Publication Title: ChemBioChem -
Description Salt dependence of the binding constants (K11) of the probes for siGL2‐2: Lys0 (○), Lys2 (▴), Lys4 (▪); Lys6 (•), and Arg6 (□). Binding constants, determined at 20 °C in phosphate buffer solutions...
Article Title: Enhanced Binding Affinity of siRNA Overhang‐Binding Fluorescent Probes by Conjugation with Cationic Oligopeptides for Improved Analysis of the siRNA Delivery Process
Publication Title: ChemBioChem -
Description Site‐specific assembly of proteins on DNA origami. A) Anchor and release of protein on DNA origami at the single‐molecule chemical reaction level. SA: streptavidin, DTT: dithiothreitol. B)...
Article Title: DNA Origami as Scaffolds for Self‐Assembly of Lipids and Proteins
Publication Title: ChemBioChem -
Description Engineering of KDM4A. A) Crystal structure (PDB ID: 2YBP) showing KDM4A active site bound with 2‐hydroxyglutarate (2HG) and H3K9me3. N198 and S288 residues are engineered in the current study....
Article Title: Allele‐Specific Inhibition of Histone Demethylases
Publication Title: ChemBioChem -
Description Structure of [Ru(η6‐p‐cymene)(pta)Cl2] (pta=1,3,5‐triaza‐7‐phosphaadamantane), known as RAPTA‐C (1).
Article Title: Towards Light‐Activated Ruthenium–Arene (RAPTA‐Type) Prodrug Candidates
Publication Title: ChemBioChem -
Description De novo sequencing of potentide pA3. Reduced potentide pA3 was digested with trypsin, resulting in two major tryptic fragments, with m/z 1295 and 2381. The sequences of the fragments were deduced...
Article Title: Potentides: New Cysteine‐Rich Peptides with Unusual Disulfide Connectivity from Potentilla anserina
Publication Title: ChemBioChem -
Description Front Cover: Structural Cues for Understanding eEF1A2 Moonlighting (ChemBioChem 2/2021) - ChemBioChemChemBioChem vol. 22, January 15, 2021
Article Title: Front Cover: Structural Cues for Understanding eEF1A2 Moonlighting (ChemBioChem 2/2021)
Publication Title: ChemBioChem -
Description Formation of dehydro‐DOPA derivatives.
Article Title: Expanding the DOPA Universe with Genetically Encoded, Mussel‐Inspired Bioadhesives for Material Sciences and Medicine
Publication Title: ChemBioChem -
Description Cartoon illustration the GLP‐1 receptor (blue). The C terminus of the peptide agonist (yellow) primarily interacts with the extracellular domain of the receptor.
Article Title: Impact of Substitution Registry on the Receptor‐Activation Profiles of Backbone‐Modified Glucagon‐like Peptide‐1 Analogues
Publication Title: ChemBioChem -
Description Cover Feature: Discovery of Six Ramoplanin Family Gene Clusters and the Lipoglycodepsipeptide Chersinamycin (ChemBioChem 1/2021) - ChemBioChemChemBioChem vol. 22, January 5, 2021
Article Title: Cover Feature: Discovery of Six Ramoplanin Family Gene Clusters and the Lipoglycodepsipeptide Chersinamycin (ChemBioChem 1/2021)
Publication Title: ChemBioChem -
Description (a) Sequences of synthetic RNA oligonucleotides. (b) Dot blot assay of two oligo RNAs treated with BP/BA. (c) Polyacrylamide gel electrophoresis analysis (odd lanes) and streptavidin gel‐shift...
Article Title: 4‐Thiouridine‐Enhanced Peroxidase‐Generated Biotinylation of RNA
Publication Title: ChemBioChem -
Description The XR‐Seq method. IP: immunoprecipitation, TFIIH: transcription factor IIH. A) Sequencing libraries after UV treatment were prepared from cell lines that had either wild‐type NER or lacked one of...
Article Title: Corrigendum: Genomic Studies Reveal New Aspects of the Biology of DNA Damaging Agents
Publication Title: ChemBioChem -
Description Cell‐Free Exploration of the Natural Product Chemical Space - ChemBioChemChemBioChem vol. 22, January 5, 2021
Article Title: Cell‐Free Exploration of the Natural Product Chemical Space
Publication Title: ChemBioChem -
Description 1H NMR spectra of 9 and 10 clearly showing the difference in the vinyl moiety resonances of these AcCoA enolate analogues.
Article Title: Acetyl Coenzyme A Analogues as Rationally Designed Inhibitors of Citrate Synthase
Publication Title: ChemBioChem -
Description Synthetic and characterization of the SPN. A) Synthetic route to SP. B) Schematic showing the preparation of SPN thorough nanoprecipitation. C) TEM of the SPN. D) DLS of the SPN. E) Average...
Article Title: Conjugated‐Polymer‐Based Nanoparticles with Efficient NIR‐II Fluorescent, Photoacoustic and Photothermal Performance
Publication Title: ChemBioChem -
Description Demonstration of the viability of cells following RTIL treatment and imaging, in low‐vacuum mode, in the SEM. Cells appear elongated which is indicative of cellular viability following treatments....
Article Title: Simultaneous Visualization of Wet Cells and Nanostructured Biomaterials in SEM using Ionic Liquids
Publication Title: ChemBioChem